围绝经期妇女内分泌变化及相关疾病

doi:10.6040/j.issn.1671-7554.0.2018.1459

摘要/Abstract

摘要： 围绝经期女性整体机能衰退,卵巢功能衰退突出,有明显的内分泌变化,可引发一系列躯体及精神心理症状甚至疾病,会明显影响该阶段及其后的生命和生活质量。目前,随着对围绝经期认识的提升,人们意识到围绝经期已不是一个简单的生理性过渡时段,而是女性不可忽视、需要倍加呵护和保健的重要生命阶段。深刻认知围绝经期的自然衰变和疾病,有助于维护自然生理,保障生命健康,提升当下及其后的生活品质。

关键词: 围绝经期, 女性, 内分泌, 疾病

Abstract: Perimenopausal women undergo a decline of the whole bodys function, especially the ovarian aging accompanied with endocrine changes, which will induce a series of physical and mental discomforts even illnesses, and will 山东大学学报 (医学版)57卷2期 -朱小明,等.围绝经期妇女内分泌变化及相关疾病 \=-affect the life and living quality in a negative way. With more knowledge of the critical changes in perimenopause, it is now realized that perimenopause is not just a simply physiological period, but an important period that need more protection and health cares. Deep understanding of the natural aging and illnesses in perimenopausal women is essential to maintain the natural physiology, guarantee the health and improve the living quality.

Key words: Perimenopause, Female, Endocrine, Diseases

中图分类号:

R711.75

朱小明,徐君碧,何人可,朱淑兰,金李雪. 围绝经期妇女内分泌变化及相关疾病[J]. 山东大学学报 (医学版), 2019, 57(2): 6-10.

ZHU Xiaoming, XU Junbi, HE Renke, ZHU Shulan, JIN Lixue. Endocrine changes in perimenopausal women and the related diseases[J]. Journal of Shandong University (Health Sciences), 2019, 57(2): 6-10.

参考文献

[1] Harlow SD, Gass M, Hall JE, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging[J]. J Clin Endocrinol Metab, 2012, 97(4): 1159-1168.
[2] van den Beld AW, Kaufman JM, Zillikens MC, et al. The physiology of endocrine systems with ageing[J]. Lancet Diabetes Endocrinol, 2018, 6(8): 647-658.
[3] Randolph JF Jr, Zheng HY, Sowers MR, et al. Change in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period[J]. J Clin Endocrinol Metab, 2011, 96(3): 746-754.
[4] Rosen MP, Johnstone E, McCulloch CE, et al. A characterization of the relationship of ovarian reserve markers with age[J]. Fertil Steril, 2012, 97(1): 238-243.
[5] Santoro N, Crawford SL, El Khoudary SR, et al. Menstrual cycle hormone changes in women traversing menopause: study of womens health across the nation[J]. J Clin Endocrinol Metab, 2017, 102(7): 2218-2229.
[6] Davis SR, Wahlin-Jacobsen S. Testosterone in women: the clinical significance[J]. Lancet Diabetes Endocrinol, 2015, 3(12): 980-992.
[7] Thilagam A. Mathematical modelling of decline in follicle pool during female reproductive ageing[J]. Math Med Biol, 2016, 33(1): 107-121.
[8] Chao KC, Ho CH, Shyong WY, et al. Anti-Mullerian hormone serum level as a predictive marker of ovarian function in Taiwanese women[J]. J Chin Med Assoc, 2012, 75(2): 70-74.
[9] 杨玲, 王建荣. 不同生理阶段更年期综合征患者Kupperman评分、体内激素和内分泌代谢指标的比较[J]. 中国老年学杂志, 2015, 35(22): 6413-6414.
[10] 陈蓉, 林守清, 凌晨, 等. 绝经过渡期妇女性激素与胰岛素敏感性的改变[J]. 现代妇产科进展, 2006, 15(9): 693-696. CHEN Rong, LIN Shouqing, LING Chen, et al. The change of sex hormones and insulin sensitivity in menopause transition women[J]. Progress in Obstetrics and Gynecology, 2006, 15(9): 693-696.
[11] Dewailly D, Andersen CY, Balen A, et al. The physiology and clinical utility of anti-Mullerian hormone in women[J]. Hum Reprod Update, 2014, 20(3): 370-385.
[12] Bremner AP, Feddema P, Leedman PJ, et al. Age-related changes in thyroid function: a longitudinal study of a community-based cohort[J]. J Clin Endocrinol Metab, 2012, 97(5): 1554-1562.
[13] Chaker L, Korevaar TI, Medici M, et al. Thyroid function characteristics and determinants: the rotterdam study[J]. Thyroid, 2016, 26(9): 1195-1204.
[14] Mosconi L, Berti V, Quinn C, et al. Perimenopause and emergence of an Alzheimers bioenergetic phenotype in brain and periphery[J]. PLoS One, 2017, 12(10): e0185926. doi:10.1371/journal.pone.0185926.
[15] Hale GE, Robertson DM, Burger HG. The perimenopausal woman: endocrinology and management[J]. J Steroid Biochem Mol Biol, 2014, 142: 121-131. doi:10.1016/j.jsbmb.2013.08.015.
[16] Roberts H, Hickey M. Managing the menopause: an update[J]. Maturitas, 2016, 86: 53-58. doi:10.1016/j.maturitas.2016.01.007.
[17] Palacios S, Castelo-Branco C, Currie H, et al. Update on management of genitourinary syndrome of menopause: a practical guide[J]. Maturitas, 2015, 82(3): 308-313.
[18] Avis NE, Colvin A, Karlamangla AS, et al. Change in sexual functioning over the menopausal transition: results from the Study of Women's Health Across the Nation[J]. Menopause, 2017, 24(4): 379-390.
[19] Baker FC, Lampio L, Saaresranta T, et al. Sleep and sleep disorders in the menopausal transition[J]. Sleep Med Clin, 2018, 13(3): 443-456.
[20] Woodard GA, Brooks MM, Barinas-Mitchell E, et al. Lipids, menopause, and early atherosclerosis in Study of Womens Health Across the Nation Heart women[J]. Menopause, 2011, 18(4): 376-384.
[21] Bjarnason NH, Alexandersen P, Christiansen C. Number of years since menopause: spontaneous bone loss is dependent but response to hormone replacement therapy is independent[J]. Bone, 2002, 30(4): 637-642.
[22] Castellani RJ, Rolston RK, Smith MA. Alzheimer disease[J]. Dis Mon, 2010, 56(9): 484-546.
[23] Roger VL, Go AS, Lloyd-Jones DM, et al. Executive summary: heart disease and stroke statistics: 2012 update: a report from the American Heart Association[J]. Circulation, 2012, 125(1): 188-197.
[24] Committee on Practice Bulletins—Gynecology. Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction[J]. Obstet Gynecol, 2013, 122(1): 176-185.
[25] 中华医学会妇产科学分会妇科内分泌学组. 异常子宫出血诊断与治疗指南[J]. 中华妇产科杂志, 2014, 49(11): 801-806.
[26] 中华医学会妇产科学分会妇科绝经学组. 围绝经期异常子宫出血诊断与治疗专家共识[J].中华妇产科杂志, 2018, 53(6): 396-401.
[27] Reed SD, Lampe JW, Qu CH, et al. Premenopausal vasomotor symptoms in an ethnically diverse population[J]. Menopause, 2014, 21(2): 153-158.
[28] Avis NE, Crawford SL, Greendale G, et al. Duration of menopausal vasomotor symptoms over the menopause transition[J]. JAMA Intern Med, 2015, 175(4): 531-539.
[29] Fisher WI, Thurston RC. Measuring hot flash phenomenonology using ambulatory prospective digital diaries[J]. Menopause, 2016, 23(11): 1222-1227.
[30] Sopień R, Wichniak A, Pawlak M, et al. Disturbances of sleep continuity in women during the menopausal transition[J]. Psychiatr Pol, 2015, 49(3): 615-623.
[31] de Zambotti M, Colrain IM, Javitz HS, et al. Magnitude of the impact of hot flashes on sleep in perimenopausal women[J]. Fertil Steril, 2014, 102(6): 1708-1715.e1. doi:10.1016/j.fertnstert.2014.08.016.
[32] Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women[J]. J Gerontol A Biol Sci Med Sci, 2002, 57(12): M772-M777.
[33] van Geel TA, Geusens PP, Winkens B, et al. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study[J]. Eur J Endocrinol, 2009, 160(4): 681-687.
[34] Phillips SK, Rook KM, Siddle NC, et al. Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy[J]. Clin Sci, 1993, 84(1): 95-98.
[35] Viña J, Lloret A. Why women have more Alzheimers disease than men: gender and mitochondrial toxicity of amyloid-beta peptide[J]. J Alzheimers Dis, 2010, 20(Suppl 2): S527-S533.
[36] Yao J, Chen SH, Mao ZS, et al. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimers disease[J]. PLoS One, 2011, 6(7): e21788. doi:10.1371/journal.pone.0021788.
[37] Sperling RA, Karlawish J, Johnson KA. Preclinical Alzheimer disease-the challenges ahead[J]. Nat Rev Neurol, 2013, 9(1): 54-58.
[38] Maki PM. Critical window hypothesis of hormone therapy and cognition: a scientific update on clinical studies[J]. Menopause, 2013, 20(6): 695-709.
[39] Craig MC, Murphy DGM. Estrogen therapy and Alzheimers dementia[J]. Annals of the New York Academy of Sciences, 2010, 1205(1): 245-253.

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