您的位置：山东大学 -> 科技期刊社 -> 《山东大学学报（医学版）》

山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (10): 42-45.doi: 10.6040/j.issn.1671-7554.0.2015.728

• 临床医学 • 上一篇    下一篇

基于Web构建山东省阿尔茨海默病临床数据库

葛树建1,2, 林炜炜3, 丛琳4, 张涛1, 韩晓娟4, 张清华4, 杜怡峰4   

  1. 1. 山东大学公共卫生学院, 山东 济南 250012;
    2. 山东大学附属省立医院科教部, 山东 济南 250021;
    3. 山东大学附属省立医院统计与病案管理科, 山东 济南 250021;
    4. 山东大学附属省立医院神经内科, 山东 济南 250021
  • 收稿日期:2015-08-03 出版日期:2015-10-10 发布日期:2015-10-10
  • 通讯作者: 杜怡峰。E-mail:duyifeng2013@163.com E-mail:duyifeng2013@163.com
  • 基金资助:
    山东省科技攻关计划(2014GGB14190)

Establishment of clinical database of Alzheimer's disease based on Web in Shandong Province

GE Shujian1,2, LIN Weiwei3, CONG Lin4, ZHANG Tao1, HAN Xiaojuan4, ZHANG Qinghua4, DU Yifeng4   

  1. 1. School of Public Health, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Science and Education, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    3. Department of Statistics and Medical Record Management, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    4. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-08-03 Online:2015-10-10 Published:2015-10-10

PDF (PC)

218

摘要： 目的 建立山东省阿尔茨海默病(AD)临床数据库,探讨其在AD患者临床、影像、检验等信息一体化管理中的价值。方法 基于J2EE框架和Oracle 10 g数据库,采用浏览器/服务器(B/S)架构,以Java为编程语言,结合AD临床诊疗特点,构建山东省AD临床数据库。结果 采用AD临床数据标准,以身份证号为惟一标识,采用分级管理权限,收集患者临床、认知评估、影像学、生化检查以及随访信息,成功建立AD数据应用体系。结论 通过规范AD数据库的相关标准,制定用于AD早期诊断的科学规范的流程,消除区域内医疗机构间AD数据孤岛,可实现信息共享的全方位业务协同。

关键词: 临床数据库, Web技术, 大数据, 信息共享, 阿尔茨海默病

Abstract: Objective To establish Alzheimer's disease (AD) clinical database in Shandong Province and investigate its applications in the managements of clinical data, imaging data and examination results of AD patients. Methods The database was constructed based on J2EE framework, Oracle 10 g database, Browser/Server(B/S) structure and Java language. Results The clinical data, cognitive assessment, imaging results, biochemical examination results and follow-up information of AD patients were collected according to the following characteristics: AD clinical data standards, ID number and hierarchical management permissions. Based on this, AD outpatient cases database, early AD diagnosis database, AD epidemiological network were established, and AD medical quality monitoring research could be pursued. Conclusion This research can normalize related standards of AD database, formulate scientific and standardized process of early AD diagnosis, eliminate regional AD information islands in different medical institutions, and realize information sharing among all the business.

Key words: Alzheimer's disease, Information sharing, Clinical database, Web technology, Big data

中图分类号: 

  • R741
[1] Lucas-Carrasco R, Skevington SM, Gómez-Benito J, et al. Using the WHOQOL-BREF in persons with dementia: a validation study[J]. Alzheimer Dis Assoc Disord, 2011, 25(4):345-351.
[2] 邓卓霞,陆锦龙,何承诚.鼻咽癌病案信息数据库的开发及应用[J].中国医药指南,2012,10(17):667-668. DENG Zhuoxia, LU Jinlong, HE Chengcheng. The development and application of medical record information database nasopharyngeal carcinoma[J]. Chinese Medicine Guide, 2012, 10(17):667-668.
[3] 黄婷婷,刘加林.基于Web肿瘤数据库应用的系统评价[J].生物医学工程学杂志,2013,30(5):946-951. HUANG Tingting, LIU Jialin. Tumor database application system based on web[J]. Journal of Biomedical Engineering, 2013, 30(5):946-951.
[4] 顾颖.专科病例数据库建设现状与对策[J].中华医学图书情报杂志,2011,20(11):20-22. GU Ying. Specialized subject cases database construction present situation and the countermeasures[J]. Chinese Journal of Medical Library and Information Science, 2011, 20(11):20-22.
[5] McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging and the Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimer's Dementia, 2011, 7(3):263-269.
[6] Chan KY, Wang W, Wu JJ, et al. Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis[J]. Lancet, 2013, 381:2016-2023.
[7] Sandmeier B, Jäger VK, Nagy G, et al. Autopsy versus clinical findings in patients with systemic sclerosis in a case series from patients of the EUSTAR database[J]. Clin Exp Rheumatol, 2015, 91(4):75-79.
[8] Mosnier A, Caini S, Daviaud I, et al. Clinical characteristics are similar across type A and B influenza virus infections[J]. PLoS One, 2015, 10(9):612-615.
[9] Lee H, Chapiro J, Schernthaner R, et al. How I do it: a practical database management system to assist clinical research teams with data collection, organization, and reporting[J]. Acad Radiol, 2015, 22(4):527-533.
[10] Athanasiadis EI, Antonopoulou K, Chatzinasiou F, et al. A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools[J]. Database (Oxford), 2014, 11(2):1124-1128.
[11] 鄂琪敏,刘加林,黎勇. 基于Web的一体化喉癌临床数据库的构建及应用[J].临床耳鼻喉头颈外科杂志, 2014, 28(15):1181-1184.E Qimin, LIU Jialin, LI Yong. A web-based integrated clinical database construction and application of laryngeal cancer[J]. Journal of Clinical Otolaryngology Head and Neck Surgery, 2014, 28(15):1181-1184.
[12] Ferré M, Caignard A, Milea D, et al. Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data[J]. Hum Mutat, 2015, 36(1):20-25.
[13] 王兵,陈颖超,梁永康,等.结直肠癌多学科专业数据库的初步建立[J].上海交通大学学报:医学版,2011,31(7):1055-1056.WANG Bing, CHEN Yingchao, LIANG Yongkang, et al. Colorectal cancer multidisciplinary professional database preliminary established[J]. Journal of Shanghai Jiaotong University: Medical Edition, 2011, 31(7):1055-1056.
[14] Bergamino M, Hamilton DJ, Castelletti L, et al. Brain tumor database, a free relational database for collection and analysis of brain tumor patient information[J]. Health Informatics J, 2015, 21(1):36-45.
[1] 闫鹏 王蓉 杜怡峰 沈伦乾. 老年性痴呆患者尿中AD7c-NTP含量的研究[J]. 山东大学学报(医学版), 2209, 47(6): 106-.
[2] 薛付忠. 健康医疗大数据驱动的健康管理学理论方法体系[J]. 山东大学学报（医学版）, 2017, 55(6): 1-29.
[3] 李江冰,宋心红,林海燕,张冬芝,李向一,许艺博,王丽,薛付忠. 健康管理人群缺血性异常心电图的影响因素[J]. 山东大学学报（医学版）, 2017, 55(6): 77-81.
[4] 李蒙蒙,王苗苗,刁雪琴,田克立,徐霞,任桂杰. 阿尔茨海默病细胞模型中lncRNA RP11-543N12.1对CDH13表达的调控作用[J]. 山东大学学报（医学版）, 2017, 55(3): 12-18.
[5] 唐毅. 阿尔茨海默病诊断标准:从临床诊断到病理生理诊断[J]. 山东大学学报（医学版）, 2017, 55(10): 14-20.
[6] 杜蘅,袁晓东. 阿尔茨海默病病因及发病机制研究进展[J]. 山东大学学报（医学版）, 2017, 55(10): 21-27.
[7] 仇成轩, 杜怡峰. 重视阿尔茨海默病和老年痴呆症的人群干预研究[J]. 山东大学学报（医学版）, 2017, 55(10): 1-6.
[8] 杜怡峰,井然. 阿尔茨海默病的诊断与治疗[J]. 山东大学学报（医学版）, 2017, 55(10): 7-13.
[9] 李懋禹,唐诗,杜怡峰. TRB3在APP/PS1转基因小鼠脑内的表达及其意义[J]. 山东大学学报（医学版）, 2016, 54(10): 1-5.
[10] 李梅, 孟庆慧, 蔡巧英, 徐雁, 范晓婷. 乙酰葛根素对Aβ25-35诱导BV-2小胶质细胞Caspase-3表达的影响[J]. 山东大学学报（医学版）, 2015, 53(10): 32-36.
[11] 赵雪莲, 于君, 谢兆宏, 曹彦军, 刘震, 王晓, 徐琳琳, 杨慧, 郑晓磊, 沈阳, 毕建忠. 线粒体自噬在阿尔茨海默病细胞模型中的作用机制[J]. 山东大学学报（医学版）, 2015, 53(10): 1-5.
[12] 王金红, 李文涛, 于树田, 董丽. 多奈哌齐对阿尔茨海默病模型大鼠下丘脑-垂体-肾上腺轴的影响[J]. 山东大学学报（医学版）, 2014, 52(7): 11-15.
[13] 钱冰，吕春娥，田晓康，高殿帅，刘志安. 钙调蛋白依赖性蛋白激酶Ⅱ在AD样大鼠海马的表达及其与细胞凋亡的关系[J]. 山东大学学报（医学版）, 2014, 52(2): 44-47.
[14] 亓珅，韩晓娟，王璐，张清华，杜怡峰. 海风藤提取物对激活的小胶质细胞IL-1β和TNF-α表达的影响[J]. 山东大学学报(医学版), 2013, 51(5): 11-14.
[15] 殷青青，刘雪平，董传芳，董雪丽，李艳菊, 罗鼎真，侯训尧. 糖基化终末产物对大鼠基底前脑胆碱能神经元的损伤作用[J]. 山东大学学报(医学版), 2012, 50(8): 20-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
版权所有 © 2018 《山东大学学报(医学版)》编辑部　
地址:山东大学科技期刊社（济南市历城区山大南路27号山东大学中心校区明德楼B座721室） 电话: 0531-88366918 E-mail: xbyxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发