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山东大学学报(医学版) ›› 2017, Vol. 55 ›› Issue (10): 21-27.doi: 10.6040/j.issn.1671-7554.0.2017.318

• 阿尔茨海默病防治专题 • 上一篇    下一篇

阿尔茨海默病病因及发病机制研究进展

杜蘅1,袁晓东1,2   

  1. 1.山东大学附属千佛山医院神经内科, 山东 济南 250014;2.山东大学附属济南市中心医院, 山东 济南 250013
  • 收稿日期:2017-04-12 出版日期:2017-10-10 发布日期:2017-10-10
  • 通讯作者: 杜蘅. E-mail:senyaheng@163.com E-mail:senyaheng@163.com
  • 基金资助:
    国家自然科学基金(31271145,81200847);山东省自然科学杰出青年基金(JQ201318)

Progress in the etiology and pathogenesis of Alzheimers disease

DU Heng1, YUAN Xiaodong1,2   

  1. 1. Department of Neurology, Shandong Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China;
    2. Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China
  • Received:2017-04-12 Online:2017-10-10 Published:2017-10-10

摘要: 阿尔茨海默病(AD)是一种主要侵袭老年人群的神经系统变性病,也是老年期痴呆的最主要原因。本病特征性的临床表现为进行性的认知功能障碍,最终导致罹患者的社会功能全面丧失。AD的病因和发病机制非常复杂,目前尚未得到充分阐明,从而严重阻碍了有效的AD防治策略的开发。本文结合相关研究领域最新进展,对AD危险因素及其主要发病机制的假说进行总结。

关键词: 阿尔茨海默病, 病因, 危险因素, 痴呆, 发病机制

Abstract: Alzheimers disease(AD)is a neurodegenerative disease majorly attacking aging population. AD is the most common type of aging-related dementia, featured by irreversible cognitive impairments and loss of social function. The 山 东 大 学 学 报 (医 学 版)55卷10期 -杜蘅,等.阿尔茨海默病病因及发病机制研究进展 \=-etiology and pathogenesis of AD have not been fully elucidated yet, which significantly deters the development of strategies for AD prevention and treatment. Here, in summary of the up-to-date research progress, we reviewed the risk factors for AD as well as the mechanisms of the pathogenesis of this neurological disorder.

Key words: Etiology, Pathogenesis, Alzheimers disease, Dementia, Risk factors

中图分类号: 

  • R741.02
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