肝内胆管细胞癌肿瘤标志物研究与临床应用进展

doi:10.6040/j.issn.1671-7554.0.2018.1011

摘要/Abstract

摘要： 肝内胆管细胞癌(ICC)是仅次于肝细胞癌的第二大肝脏恶性肿瘤,且发病率呈逐年上升趋势。ICC早期症状较隐匿、进展快、恶性程度高、预后较差。早诊断、早治疗可有效改善ICC患者的生存水平。通过检测ICC患者组织及外周血清肿瘤标志物,深入开展ICC发生、发展、复发与转移相关研究,对于阐明ICC发病机制以及研究新的ICC早期诊断与治疗方法,具有重要的研究意义和应用价值。

关键词: 肝内胆管细胞癌, 肿瘤标志物, 诊断, 预后

Abstract: Intrahepatic cholangiocarcinoma(ICC)is the second most common primary liver tumor with increasing incidence worldwide. The early symptoms are insidious. With rapid progression and high malignancy, the tumor shows poor 山东大学学报 (医学版)56卷10期 -高春芳,等.肝内胆管细胞癌肿瘤标志物研究与临床应用进展 \=-outcomes. Early diagnosis and treatment can effectively improve patients’ survival. Detection of the cancer biomarkers is conducive not only for related studies on the genesis, development and recurrence of ICC, but also for its diagnosis and treatment.

Key words: Intrahepatic cholangiocarcinoma, Cancer biomarkers, Diagnosis, Prognosis

中图分类号:

R574

高春芳,黄晨军. 肝内胆管细胞癌肿瘤标志物研究与临床应用进展[J]. 山东大学学报 (医学版), 2018, 56(10): 24-30.

GAO Chunfang, HUANG Chenjun. Cancer biomarkers of intrahepatic cholangiocarcinoma and the clinical application[J]. Journal of Shandong University (Health Sciences), 2018, 56(10): 24-30.

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