B7H4、CA125及P53在上皮性卵巢癌中的表达及意义

山东大学学报(医学版)

B7H4、CA125及P53在上皮性
卵巢癌中的表达及意义

孔凡荣¹，王黎明¹，戴淑真¹，孙显璐²，吕艳华¹

（青岛大学医学院附属医院 1.妇科; 2.病理科，山东青岛 266003）

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-02-16 发布日期:2009-02-16
通讯作者: 王黎明

Expressions of B7H4, CA125 and P53 in epithelial
ovarian cancer and their clinical value

KONG Fanrong¹,　WANG Liming¹,　DAI Shuzhen¹,　SUN Xianlu²,　L Yanhua¹

(1. Department of Gynecology and obstetrics; 2. Department of Pathology, Affiliated Hospital of
Medical College of Qingdao University, Qingdao 266003, Shandong, China)

Received:1900-01-01 Revised:1900-01-01 Online:2009-02-16 Published:2009-02-16
Contact: WANG Liming

摘要/Abstract

摘要： 目的探讨B7H4、CA125及P53在原发上皮性卵巢癌（EOC）中的表达及其之间的相互关系，以及与预后的关系。方法用免疫组织化学PV6000二步法测定B7H4、CA125及P53在70例上皮性卵巢癌、20例正常卵巢组织和20例良性卵巢肿瘤中的表达。结果B7H4在原发上皮性卵巢癌组织中阳性表达率88.6% (62/70)高于卵巢良性上皮肿瘤（45%）及正常卵巢组织(0%)(P<0.05)。上皮性卵巢癌组织中CA125阳性表达率为77.1%（54/70），与B7H4表达呈正相关（r=0.720）。上皮性卵巢癌组织P53阳性表达率为68.6%（48/70）低于B7H4（P<0.05）。多因素Cox回归分析显示,上皮性卵巢癌的预后与FIGO分期、术后残癌灶大小、B7H4的表达、细胞分化程度、CA125的表达、淋巴结转移的有无及P53的表达相关；单因素分析显示，B7H4表达越强，平均生存时间越短，5年累积生存率越低。结论上皮性卵巢癌中B7H4表达上调，且B7H4表达与CA125的表达呈正相关，高于P53的表达。B7H4为卵巢癌总生存期的独立危险因素，且有可能作为上皮性卵巢癌新的诊断和预后指标。

关键词: 卵巢肿瘤, B7H4, 蛋白质p53, 预后

Abstract: To investigate expressions of B7H4, CA125 and P53 in primary epithelial ovarian cancer (EOC) and to explore their relationship with prognosis. MethodsExpressions of B7H4, CA125 and P53 were determined by PV6000 twostep immunohistochemistry in 70 cases of EOC, 20 cases of normal ovarian tissues and 20 cases of benign ovarian tumors. ResultsThe positive rate of B7H4 in epithelial ovarian cancer was 88.5%(62/70), and it was significantly higher than that in benign ovarian epithelial tumors (45%) and normal ovarian tissues (0%) .The positive rate of CA125 in epithelial ovarian cancer was 77.1%, and it positively correlated with B7H4. The positive rate of P53 in epithelial ovarian cancer was 68.6% (48/70), and was significantly lower than B7H4 (P<0.05). Multivariate COX regression analysis showed that prognosis of epithelial ovarian cancer was correlated with the FIGO stage, residual tumor size, B7H4′s positive expression, cell differentiation, CA125′s positive expression, P53′s positive expression and lymph node metastasis. Single factor KaplanMeier analysis showed that the intensity the B7H4 positive expression was negatively correlated with the average survival time of patients and the cumulative fiveyear survival rates. ConclusionB7H4 overexpresses in epithelial ovarian cancer and positively correlates with CA125 and is higher than P53 expression. B7H4 is an independent risk factor of total life span of epithelial ovarian cancer patients. The stronger the B7H4 expression, the shorter the average life time and the lower the cumulative fiveyear survival rate.

Key words: Ovarian neoplasms, B7H4, Protein p53, Prognosis

中图分类号:

R737.31

孔凡荣1 ，王黎明1 ，戴淑真1 ，孙显璐2 ，吕艳华1
. B7H4、CA125及P53在上皮性
卵巢癌中的表达及意义[J]. 山东大学学报(医学版), 2009, 47(02): 74-77.

KONG Fanrong¹,　WANG Liming¹,　DAI Shuzhen¹,　SUN Xianlu²,　L Yanhua¹

. Expressions of B7H4, CA125 and P53 in epithelial
ovarian cancer and their clinical value[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(02): 74-77.

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