Abstract: Objective: To explore the protection of Xingnaojing injection(XI) on rats with acute brain ischemia. Methods： Seventy-five rats were randomly divided into three groups( 25 in each). The control and model groups were subjected to 0.9% Nacl(4ml/Kg)and the XI group was subjected to XI (4ml/Kg) through the abdominal cavity, twice a day for 5 days. Then the two sides of the general carotids of the model and XI groups were tied-up to cause acute brain ischemia. After the operations, they were subjected to double dosages. Serum tumor necrosis factor-a(TNF-α), intercellular adhension molecule-1(ICAM1) levels, brain edema and preparations were determined. Results： Serum TNF-α, ICAM-1 levels and brain edema of the model group were higher than those of the control and XI groups(P＜0.01). The injury degree of preparations of the model group was heavier than that of the XI group. There were positive correlations between TNF-α and ICAM-1（P＜0.01）, between TNF-α and brain edema(P＜0.01),and between ICAM1 and brain edema（P＜0.01. Conclusion： XI could inhibit the inflammatory reaction and decrease brain edema, and protect the acute brain ischemia of rats.

Key words: Xingnaojing injection, Brain ischemia, Tumor necrosis factor-a, Intercellular adhension molecule-1, Brain edema, Preparations, Rats, Wistar