Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (6): 65-70.doi: 10.6040/j.issn.1671-7554.0.2024.0207

• Clinical Medicine • Previous Articles    

Abnormalities of morphology and function of meibomian gland and their effects on tear film in patients with systemic lupus erythematosus

KANG Suifang1, WANG Yingxue2, ZHANG Qichen1, WANG Zhilun2, YIN Zhe2, XIAO Juan3, CHEN Guoling1   

  1. 1. Department of Ophthalmology;
    2. Department of Rheumatology;
    3. Department of Hospital Infection Management, The Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Published:2024-07-15

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Abstract: Objective To observe the abnormalities of morphology and function of meibomian gland and their effects on tear film in systemic lupus erythematosus(SLE)patients. Methods Eighty-two eyes of 41 SLE patients were recruited as SLE group and 52 eyes of 26 healthy volunteers were recruited as control group. The grade of meibomian gland dropout was evaluated by Keratograph 5M ocular surface analyzer, the tear film lipid layer thickness(TFLLT)was measured by LipiView interferometer, the dynamic tear film objective scatter index(OSI)was measured by the double-pass Optical Quality Analysis System(OQAS II). The eyelid margin, meibomian gland secretion, fluorescein breakup time(FBUT)and fluorescein cornea staining(FCS)were observed under slit lamp microscope. Schirmer Ⅰ test(SⅠt)was conducted using standard Schirmer paper strip. The correlations between meibomian gland parameters and tear film function were assessed by Spearman rank correlation analysis. Results Compared with the control group, the meibomian gland dropout score(MGDS), meibomian gland secretion score(MGSS), eyelid margin score(EMS), dynamic tear film OSI and FCS were higher, while FBUT and TFLLT were lower in SLE group(all P<0.05). There was no significant difference in the SⅠt between SLE group and control group(P>0.05). MGDS, MGSS, and EMS were negatively correlated with FBUT(rMGDS=-0.335, rMGSS=-0.424, rEMS=-0.318, P<0.05), while MGDS was positively correlated with dynamic tear film OSI(r=0.254, P<0.05). Conclusion Abnormalities in the morphology and function of meibomian glands can be caused by SLE, leading to decreased TFLLT and tear film stability.

Key words: Systemic lupus erythematosus, Autoimmune disease, Meibomian gland, Tear film, Ocular surface disease

CLC Number: 

  • R771.3
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