Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (3): 118-124.doi: 10.6040/j.issn.1671-7554.0.2020.052

Previous Articles    

Clinical manifestation and prognosis of adenomatoid odontogenic tumor: an analysis of 15 cases

YU Lu1, WANG Caijiao2, LIU Chao3, SUN Mingxia4, PENG Huahai3, YU Wenqian1, XU Xin1, TAN Wanye3   

  1. 1. Department of Implantology, School and Hospital of Stomatology, Shandong University &
    Shandong Key Laboratory for Dental Materials and Oral Tissue Regeneration &
    Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan 250012, Shandong, China;
    2. Department of Pathology, School and Hospital of Stomatology, Shandong University &
    Shandong Key Laboratory for Dental Materials and Oral Tissue Regeneration &
    Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan 250012, Shandong, China;
    3. Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. Department of Oral Medicine, Qilu Hospital of Shandong University, Jinan 250012, Shandong China
  • Online:2020-03-10 Published:2022-09-27

PDF (PC)

46

Abstract: Objective To explore the clinical manifestation, diagnosis, treatment and prognosis of adenomatoid odontogenic tumor(AOT). Methods The clinical data of AOT patients treated during July 2011 and July 2019 were retrospectively analyzed, including clinical manifestation, diagnosis, treatment and prognosis. The patients were divided into maxillary group and mandible group based on the site of tumor. The association among tumor size, tumor site, patients gender and age was analyzed with Fishers exact probability test. Results Altogether 15 cases were enrolled, including 7 male and 8 female. There were 9 in the maxillary group and 6 in the mandible group. Statistical analysis revealed thattumor with diameters >3 cm were more likely to occur in the mandible. All cases received curettage and had good treatment effects. During the follow-up of 5 months to 8 years, all patients showed good prognosis, and no serious complications or recurrence were observed. Conclusion Adenomatoid odontogenic tumor is rare and pathological examination is necessary for confirmation. Curettage is an effective treatment which has favorable therapeutic effects.

Key words: Adenomatoid odontogenic tumor, Odontogenic tumor, Jaw tumor, Oral and maxillofacial tumor, Clinical case analysis

CLC Number: 

  • R574
[1] La Monaca G, Pranno N, di Gioia CRT, et al. Surgical management of extrafollicular variant of adenomatoid odontogenic tumor in the maxillary posterior region [J]. Case Rep Dent, 2019. doi: 10.1155/2019/3787696.
[2] Adel KE. WHO classification of head and neck tumors [M]. 4th edition. Lyon: International Agency for Research on Cancer, 2017: 221-222.
[3] Prasad G, Nair P, Thomas S, et al. Extrafollicular adenomatoid odontogenic tumour [J]. BMJ Case Rep, 2011, 2011. doi:10.1136/bcr.03.2011.3963.
[4] 李铁军. 牙源性肿瘤的WHO(2005)新分类 [J]. 现代口腔医学杂志, 2007, 21(4): 337-339.
[5] Wright JM, Vered M. Update from the 4th edition of the World Health Organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors [J]. Head Neck Pathol, 2017, 11(1): 68-77.
[6] Philipsen HP, Reichart PA, Siar CH, et al. An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study [J]. Oral Pathol Med, 2007, 36(7): 383-393.
[7] Rick GM. Adenomatoid odontogenic tumor [J]. Oral Maxillofac Surg Clin North Am, 2004, 16(3): 333-354.
[8] 王应霞, 潘国庆, 雷梓, 等. 牙源性腺样瘤9例临床病理分析 [J]. 临床与实验病理学杂志, 2019, 35(6): 702-704. WANG Yingxia, PAN Guoqing, LEI Zi, et al. Clinical and pathological analysis of 9 cases of adenomatoid odontogenic tumors [J]. Chinese Journal of Clinical and Experimental Pathology, 2019, 35(6): 702-704.
[9] Bilodeau EA, Collins BM. Odontogenic cysts and neoplasms [J]. Surg Pathol Clin, 2017, 10(1): 177-222.
[10] Kurra S, Gunupati S, Prasad PR, et al. An adenomatoid odontogenic cyst(AOC)with an assorted histoarchitecture: a unique entity [J]. J Clin Diagn Res, 2013, 7(6): 1232-1235.
[11] Reichart PA, Philipsen HP, Khongkhunthian P, et al. Immunoprofile of the adenomatoid odontogenic tumor [J]. Oral Dis, 2017, 23(6): 731-736.
[12] Chhavi Jindal, Reena Bhola Sarkar, Jessica Grewal, et al. Mural adenomatoid odontogenic tumour as anterior mandibular swelling: a diagnostic challenge [J]. J Clin Diagn Res, 2014, 8(6): ZD25-ZD27.
[13] Sharma N, Passi S, Kumar VV. Adenomatoid odontogenic tumor: as an unusual mandibular manifestation [J]. Contemp Clin Dent, 2012, 3(Suppl 1): S29-32.
[14] Bhatt R, Dave J, Nalawade TM, et al. Adenomatoid odontogenic tumour in mandible in a 14-year-old boy [J]. BMJ Case Rep, 2013, 2013.doi: 10.1136/bcr-2013-010287.
[15] Narayanan VS, Naidu G, Ragavendra R, et al. Adenomatoid odontogenic tumor of the mandible with unusual radiographic features: a case report [J]. Imaging Sci Dent, 2013, 43(2): 111-115.
[16] Rai HK, Pai SM, Dayakar A, et al. Adenoid ameloblastoma with dentinoid. A rare hybrid variant [J]. Oral Maxillofac Pathol, 2017, 21(2): 319.
[17] Rezvani. G, Donoghue. M, Reichart. PA, et al. Case presentation of concomitant and contiguous adenomatoid odontogenic tumor andfocal cemento-ossifying dysplasia [J]. Open Dent J, 2015, 9: 340-345. doi:10.2174/1874210601509010340.
[18] Dhupar V, Akkara F, Khandelwal P. An unusually large aggressive adenomatoid odontogenic tumor of maxilla involving the third molar: a clinical case report [J]. Eur J Dent, 2016, 10(2): 277-280.
[19] Shaikh S, Bansal S, Desai RS, et al. Aggressive adenomatoid odontogenic tumor of the mandible: a rare case report and review of the literature [J]. J Oral Maxillofac Pathol, 2018, 22(Suppl 1): S11-S15.
[20] Kalia V, Kalra G, Kaushal N, et al. Maxillary adenomatoid odontogenic tumor associated with a premolar [J]. Ann Maxillofac Surg, 2015, 5(1): 119-122.
[21] Virupakshappa D, Rajashekhara BS, Manjunatha BS, et al. Adenomatoid odontogenic tumour in a 20-year-old woman [J]. BMJ Case Rep, 2014, 2014. doi: 10.1136/bcr-2013-010436.
[22] Erdur EA, Ileri Z, Ugurluoglu C, et al. Eruption of an impacted canine in an adenomatid odontogenic tumor treated with combined orthodontic and surgical therapy [J]. Am J Orthod Dentofacial Orthop, 2016, 149(6): 923-927.
[23] Nomura M, Tanimoto K, Takata T, et al. Mandibular adenomatoid odontogenic tumor with unusual clinicopathologic features [J]. J Oral Maxillofac Surg, 1992, 50(3): 282-285.
[24] Takigami M, Uede T, Imaizumi T, et al. A case of adenomatoid odontogenic tumor with intracranial extension [J]. No Shinkei Geka, 1988, 16(6): 775-779.
[25] Zhou CX, Gao Y. Adenomatoid odontogenic tumor: a report of a rare case with recurrence [J]. J Oral Pathol Med, 2007, 36(7): 440-443.
[1] WANG Jing, LIU Xiaozhuan, XU Fangfang. Genetic testing and prenatal diagnosis for a pedigree affected with ATP7B gene variation in Wilson disease [J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 32-36.
[2] Zhuxiu CHU,Wenjing ZHAO,Xiaoyan LI,Xiaoli KONG,Tingting MA,Liyu JIANG,Qifeng YANG. Significance of neoadjuvant chemotherapy and molecular marker changes in 218 women with breast cancer [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 130-139.
[3] Jianhua JU,Zhenye YANG,Qinglian LI,Ya'nan HAN,Yanqing LI,Yijun QIAO,Hu YANG,Huaran ZHANG. Advances on drugs derived from microbial sources and future perspectives [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 43-50,63.
[4] TIAN Yaotian, WANG Bao, LI Yeqin, WANG Teng, TIAN Liwen, HAN Bo, WANG Cuiyan. Machine learning models based on interpretive CMR parameters can predict the prognosis of pediatric myocarditis [J]. Journal of Shandong University (Health Sciences), 2021, 59(7): 43-49.
[5] XIA Xiaona, HUANG Zhaodi, REN Qingguo, LIU Feng, DENG He, REN Guorong, DUAN Jiandong, WANG Shaoyu. Value of double-phase enhancement CT scan in the differential diagnosis of 182 benign and malignant thyroid nodules [J]. Journal of Shandong University (Health Sciences), 2021, 59(7): 57-62.
[6] WANG Ning, GUO Zhenjiang, ZHANG Yuanyuan, WANG Jing, GUO Wei, WANG Jinrong, CUI Zhaobo. Value of regular ultrasound examination in the diagnosis and treatment of deep venous thrombosis associated with central venous access device [J]. Journal of Shandong University (Health Sciences), 2021, 59(7): 63-67.
[7] Jiaojiao DU,Xianghua ZHUANG,Shihong CHEN,Xuemeng WANG,Dongqing JIANG,Fei WU,Xiaolin HAN,Mengyu HUA,Yuwen SONG. Changes of serum IL-31 and IL-33 levels in postmenopausal patients with osteoporosis [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 45-50.
[8] Shihong CHEN. Progress in glucocorticoid-induced osteoporosis [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 33-37.
[9] Haipeng SI,Wencan ZHANG,Le LI,Xin ZHOU. Research advances on risk factors, diagnosis and treatment of Kümmell's disease [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 25-32.
[10] Minqi LI,Juan DU,Panpan YANG,Yuying KOU,Shanshan LIU. Research progress of oxidative stress regulating osteoporosis [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 16-24.
[11] Xiaoguang CHENG,Yanhui LU. Osteoporosis in men: a chronically overlooked problem [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 5-9.
[12] JIANG Yong, SONG Jiangang, ZHU Daxia, LIU Lijian. Effects of naringenin on acute lung injury induced by sepsis via regulating the activation of NLRP3 inflammasome in macrophages [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 14-21.
[13] JIA Mingwang, LIAO Guangyuan, XIONG Mingmei, XU Wenting, WANG Yinling, WANG Yichun. Clinical analysis of outcomes of 84 pregnant women with pulmonary hypertension [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 34-39.
[14] ZHEN Qiulai, LYU Xinran, YE Hui, DING Xuchao, CHAI Xiaoxue, HU Xin, ZHOU Ming, CAO Lili. Predicting colon cancer prognosis genes and clinical application value based on TCGA database [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 64-71.
[15] Yilong YIN,Xiaoming XI. Advances in the intelligent diagnosis of eye diseases [J]. Journal of Shandong University (Health Sciences), 2020, 58(11): 33-38.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd