Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (1): 55-61.doi: 10.6040/j.issn.1671-7554.0.2018.1089

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Anti-inflammatory mechanism of ephedra treatment of asthma based on network pharmacology

CHEN Ou1,2, LI Guoyong3, LIU Aihong2, ZHU Xiaobo2, CHEN Shaojie2, WANG Yibiao2   

  1. 1. Community Room, School of Nursing, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Pediatrics, The Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    3. Certification Review Center of Shandong Food and Drug Administration, Jinan 250014, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the pathogenesis of asthma by predicting the anti-inflammatory targets and related signaling pathway of ephedra therapy based on network pharmacology. Methods The active ingredients of ephedra were searched and screened in TCMSP database. The targets of ingredients were predicted with PharmMapper and molecular docking was performed. Then ingredients-targets network was established and analyzed with cytoscape3.6.1. The anti-inflammatory targets in TTD database were searched to build PPI network, which was merged with the ingredients-targets network to screen anti-inflammatory targets connected with ephedra. The vivo reaction network of ephedra anti-inflammatory targets against asthma was constructed to screen anti-inflammatory targets related to asthma. KEGG enrichment analysis was performed with Enrichr database and cytoscape3.6.1. Results Altogether 23 active ingredients were screened and 156 targets were obtained. Epidermal active growth factor receptor(EGFR), E-selectin(SELE), macrophage migration inhibitory factor(MIF), mitogen-activated protein kinase 14(MAPK14)might be the important anti- 山 东 大 学 学 报 (医 学 版)57卷1期 -陈欧,等.网络药理学预测麻黄治疗哮喘的抗炎作用机制 \=-inflammatory targets of ephedra treatment of asthma. All these pathways had epithelial cell signaling pathways. Conclusion The anti-inflammatory mechanism of ephedra treatment of asthma may be related to EGFR, SELE, MIF, MAPK14 and their signaling pathways. To prevent the exacerbation of asthma, instead of a single pathway or a single target, all these targets and their signaling pathways should be controlled holistically.

Key words: Asthma, Ephedra, Network pharmacology, Anti-inflammatory, Target prediction, Pathway

CLC Number: 

  • R725.4
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