Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (12): 62-67.doi: 10.6040/j.issn.1671-7554.0.2018.632

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Significance of ultrasonography and MRI in the prenatal diagnosis of cleft lip and palate

TIAN Mimi1,2, XIAO Lianxiang2, JIAN Nan1,3, ZHAO Hui1,4, WEI Xinhong2, SHI Yan1,2, LI Guan2,5, ZHANG Shuai1,2, LIN Xiangtao1,6   

  1. 1. School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Shandong Medical Imaging Research Institute, Jinan 250021, Shandong, China;
    3. CT Department, Heze Municipal Hospital, Heze 274031, Shandong, China;
    4. Department of Imaging, Shandong Provincial Western Hospital, Jinan 250021, Shandong, China;
    5. College of Radiology, Taishan Medical University, Taian 271016, Shandong, China;
    6. Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To evaluate the accuracy of ultrasound(US)and magnetic resonance imaging(MRI)in the diagnosis of fetal cleft lip and palate. Methods Pregnant women suspected of fetal facial malformations or unable to clearly display normal maxillofacial anatomy were enrolled in the prospective blinded case-control study. The US and MRI images were reviewed in a blinded fashion by experienced radiologists without knowledge of indications or prior imaging findings. The prenatal US and MRI diagnosis were compared with the postnatal results. Receiver operating characteristic curve(ROC)analysis of data by SPSS 20.0 software was conducted to compare the diagnostic efficiency of 山 东 大 学 学 报 (医 学 版)56卷12期 -田迷迷,等.超声和MRI对胎儿唇腭裂的诊断价值 \=-US and MRI. Diagnostic confidence was divided into four levels. Results All of the 47 fetuses had craniofacial anomaly, including isolated cleft lip in 23 cases, unilateral cleft lip and alveolus in 1 case, cleft lip and palate in 19 cases, and isolated cleft palate in 4 cases. The accuracy, sensitivity and specificity of both US and MRI in the diagnosis of cleft lip were 100%. The accuracy of US and MRI in the detection of cleft palate was 93.6% vs 48.9%. The AUC of US and MRI was 0.954 vs 0.704 for the detection of cleft lip and palate(P<0.05). The diagnostic confidence of MRI in the diagnosis or exclusion of cleft lip and palate was higher than that of US(91.5% vs 44.7%). Conclusion MRI is superior to US in the diagnosis of cleft lip and palate, which can serve as an auxiliary diagnostic method, especially when US is unable to confirm the presence of complicated cleft palate.

Key words: Ultrasonography, Magnetic resonance imaging, Fetus, Cleft lip and palate

CLC Number: 

  • R445.1
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