Abstract: Objective To analyze the proportion and changes of causes resulting in the cancellation of fresh embryo transfer of in vitro fertilization(IVF)/intracytoplasmic sperm injection(ICSI)from 2008 to 2017 in the Reproductive Hospital Affiliated to Shandong University. Methods A retrospective analysis was performed among 17 601 cycles of IVF/ICSI fresh embryo transfer cancellation, including 3 018 cycles during 2008 and 2012, and 14 583 cycles during 2013 and 2017. The causes of cancellation included ovarian hyperstimulation syndrome(OHSS), high level of serum progesterone, endometrial factors, poor embryo quality, hydrosalpinx, and others. Further analysis was performed 山 东 大 学 学 报 (医 学 版)56卷9期 -范华蕊,等. 2008~2017年体外受精/卵胞浆内单精子显微注射周期取消新鲜胚胎移植的原因构成与变化 \=-according to the female age(<35 years and ≥35 yrs)and different protocols. Results The major cause for cancellation was OHSS risk, which showed an increasing trend in all age groups in the past 10 years. For women ≥35 years, the dominant cause was poor embryo quality, whereas for women <35 years, the major cause was OHSS risk. An obvious increase was observed in the proportion of hydrosalpinx in all age groups in the past 10 years. For long, GnRH antagonist and ultra-long GnRHa protocols, the prominent cause for cancellation was OHSS risk. For short, mini-stimulation protocols, the major cause was poor embryo quality. Conclusion OHSS risk was the commonest cause for cancellation of fresh embryo transfer, followed by poor embryo quality and endometrial factors. Embryo quality was a challenge for female of advanced aged. Effective methods could be considered to reduce the rate of cancellation, such as preventing ovarian hyperresponsiveness, improving embryo quality, and controlling pelvic inflammation.

Key words: Fresh embryo transfer, Embryos freezing, Ovarian hyperstimulation syndrome, Endometrium, Progesterone