Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (5): 30-34.doi: 10.6040/j.issn.1671-7554.0.2018.223

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Prognosis related factors of patients with ovarian Sertoli-Leydig cell tumor after fertility-preserving surgery

YANG Ni1, CAO Dongyan1, YANG Jiaxin1, YOU Yan2, SHEN Keng1   

  1. 1. Department of Obstetrics and Gynecology;
    2. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science &
    Peking Union Medical College, Beijing 100730, China
  • Received:2018-02-14 Published:2022-09-27

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Abstract: Objective To evaluate the prognosis and its related factors of patients with ovarian Sertoli-Leydig cell tumor(SLCT)after fertility-preserving surgery. Methods Detail clinical data, including survival rates, recurrence, death and fertility states, of 52 SLCT patients after fertility-preserving surgery in Peking Union Medical College Hospital were retrospectively reviewed. Results Forty-one cases showed androgenic manifestations, while 11 cases had no endocrine symptoms. All tumors located in unilaterl ovary; the mean tumor diameter was 10.0 cm(range 2-34 cm); fifty cases were at stage Ⅰ(36 cases at stage ⅠA, 14 cases at stage ⅠC), one was at stage ⅢC, ones stage was unknown; four(7.7%)tumors were well differentiated, 14(26.9%)were intermediately differentiated, 34(65.4%)were poorly differentiated. In the poorly differentiated tumors, 9 had a retiform pattern, 4 had heterologous elements. Six patients(11.5%)underwent cystectomy, 36(69.2%)underwent unilateral salpingo-oophorectomy, and 10(19.2%)underwent standard staging surgery. Twenty-nine patients received systematic chemotherapy(1-4 courses of treatment)after 山 东 大 学 学 报 (医 学 版)56卷5期 -杨旎,等.卵巢支持间质细胞肿瘤保留生育功能治疗的预后及相关因素 \=-the initial surgery. The average follow-up period was 72 months; six cases recurred, in whom 3 cases died. The poor prognosis was correlated with no endocrine symptoms, bigger tumor size, clinical stage >ⅠA, and probably correlated with poor differentiation, retiform pattern and heterologous elements, while not correlated with surgery type and postoperative chemotherapy. Conclusion SLCT is a rare type of sex cord-stromal tumor of the ovary. Most SLCT patients have androgenic manifestations and abdominal masses, and tumors without endocrine changes may indicate more aggressive biological behaviors. The prognosis is correlated with tumor size and clinical stage, and probably correlated with the degree of differentiation. Conservative surgery is acceptable for young patients wishing to preserve fertility, and postoperative adjuvant chemotherapy and long-term follow up are recommended to those with high-risk factors of recurrence.

Key words: Ovarian Sertoli-Leydig cell tumor, Fertility-preserving therapy, Prognosis

CLC Number: 

  • R711.75
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