Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (9): 108-112.doi: 10.6040/j.issn.1671-7554.0.2022.0099

Previous Articles     Next Articles

Angiosarcoma of the uterus: a report of 2 cases and literature review

WANG Lihui, GAO Min, KONG Beihua   

  1. Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-02

PDF (PC)

89

Abstract: Objective To analyze 2 cases of angiosarcoma of the uterus misdiagnosed as other types of uterine malignancies and to review relevant literature, so as to improve the clinicians awareness of the clinicopathological feature, treatment and prognosis of this disease. Methods The clinical data of 2 cases of uterine angiosarcoma were collected and analyzed, and relevant literature was reviewed. Results Case 1 received radical surgery and 6 cycles of ifosfamide + epirubicin chemotherapy after surgery. The postoperative progression-free survival was 62 months and the overall survival was 66 months. Case 2 received radical surgery and 4 cycles of ifosfamide + epirubicin chemotherapy, with no sign of recurrence. Conclusion Angiosarcoma of the uterus is extremely rare in clinical practice and is easily misdiagnosed. It should be differentiated from other uterine malignancies by pathology and immunohistochemistry. The combination of surgery and adjuvant chemotherapy might be effective.

Key words: Angiosarcoma, Uterine malignancy, Misdiagnosis, Therapy, Prognosis

CLC Number: 

  • R737.33
[1] Young RJ, Brown NJ, Reed MW, et al. Angiosarcoma[J]. Lancet Oncol, 2010, 11(10): 983-991.
[2] Chinczewski L, Taube ET, Feldhaus FW, et al. Angiosarcomas of primary gynecologic origin—a case series and review of the literature[J]. Anticancer Res, 2020, 40(10): 5743-5750.
[3] Hara T, Miyoshi A, Kamei Y, et al. Epithelioid angiosarcoma arising from a huge leiomyoma: a case report and a literature review[J]. Case Rep Obstet Gynecol, 2018, 2018: 7591769. doi: 10.1155/2018/7591769.
[4] Chen TW, Burns J, Jones RL, et al. Optimal clinical management and the molecular biology of angiosarcomas[J]. Cancers(Basel), 2020, 12(11): 3321.
[5] Kruse A, Sep S, Slangen BFM, et al. Angiosarcomas of primary gynecologic origin: a clinicopathologic review and quantitative analysis of survival[J]. Int J Gynecol Cancer, 2014, 24(1): 4-12.
[6] Lahat G, Dhuka AR, Hallevi H, et al. Angiosarcoma: clinical and molecular insights[J]. Ann Surg, 2010, 251(6): 1098-1106.
[7] 熊云棋, 吴霞. 子宫上皮样血管肉瘤1例[J]. 实用妇产科杂志, 2015, 31(12): 938-939.
[8] Cao J, Wang J, He C, et al. Angiosarcoma: a review of diagnosis and current treatment[J]. Am J Cancer Res, 2019, 9(11): 2303-2313.
[9] Merfeld E, Gabani P, Spraker MB, et al. Clinical outcomes and prognostic features of angiosarcoma: significance of prior radiation therapy[J]. Clin Oncol(R Coll Radiol), 2019, 31(4): 232-241.
[10] Olawaiye AB, Morgan JA, Goodman A, et al. Epithelioid angiosarcoma of the uterus: a review of management[J]. Arch Gynecol Obstet, 2008, 278(5): 401-404.
[11] Hwang JP, Lim SM. Uterine epithelioid angiosarcoma on F-18 FDG PET/CT[J]. Nucl Med Mol Imaging, 2013, 47(2): 134-137.
[12] Soydal C, Kucuk ON, Gecim EI, et al. The prognostic value of quantitative parameters of 18F-FDG PET/CT in the evaluation of response to internal radiation therapy with yttrium-90 in patients with liver metastases of colorectal cancer[J]. Nucl Med Commun, 2013, 34(5): 501-506.
[13] 刘梅, 巴恩平, 赵坡, 等. 上皮样血管肉瘤的临床病理分析[J]. 中华病理学杂志, 2002, 31(5): 22-25. LIU Mei, BA Enping, ZHAO Po, et al. A clinicopathological study of fifteen epithelioid angiosarcoma[J]. Chinese Journal of Pathology, 2002, 31(5): 22-25.
[14] Liang D, Li L, He Y, et al. Primary uterine angiosarcoma: a case report in China with the literature review[J]. Indian J Pathol Microbiol, 2020, 63(Supplement): S94-S97.
[15] Sindhu S, Gimber LH, Cranmer L, et al. Angiosarcoma treated successfully with anti-PD-1 therapy—a case report[J]. J Immunother Cancer, 2017, 5(1): 58.
[16] Konishi Y, Sato H, Fujimoto T, et al. A case of primary uterine angiosarcoma: magnetic resonance imaging and computed tomography findings[J]. Int J Gynecol Cancer, 2007, 17(1): 280-284.
[1] LV Yan-Feng, DING Ke, WANG Jian-Xin, YU Hua-Long, BEI Shao-Sheng. Canceration of chronic anal fistula [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 55-57.
[2] ZHANG Shi-Bao, LIU Qing-Yong, RUAN Xi-Yun, CHEN Jie, ZHANG Jian-Jun, LI Zong-Wu, YANG Guang-Xiao, WANG Quan-Ying. onstruction and identification of the expression vector of
NT4-SAC-HA2-TAT fusion gene [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 15-19.
[3] ZHENG Su, CHEN Shuhua, LI Hua, DENG Jie, CHEN Chunhong, WANG Xiaohui, FENG Weixing, HAN Xiaodi, ZHANG Yujia, LI Na, LI Mo, FANG Fang. Correlation between EEG variations and BASED evaluation of the efficacy of ACTH treatment in 54 cases of infantile spasms [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 91-96.
[4] HAN Jing, JIA Chunling. Effects of periodontal basic therapy on postoperative pneumonia in patients with lung cancer before thoracic surgery [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 113-118.
[5] RUAN Xiangyan, CHENG Jiaojiao, DU Juan, GU Muqing. Ovarian tissue cryopreservation and preservation [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 24-30.
[6] HE Shiqing, LI Wanwan, DONG Shuqing, MOU Jingyi, LIU Yuying, WEI Siyu, LIU Zhao, ZHANG Jiaxin. Construction of a prognostic risk model of pyroptosis-related genes in breast cancer based on database [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 34-43.
[7] WANG Wenjing, LIU Boce, BI Jianhai, HUO Ran. Efficacy of ultrasound-guided sclerotherapy with pingyangmycin and lauromacrogol in 94 cases of cystic lymphatic malformation [J]. Journal of Shandong University (Health Sciences), 2022, 60(8): 72-78.
[8] ZHANG Yufeng, XU Min, XING Xiuli, PANG Shuguang, HU Keqing. Epidemiological characteristics of 689 patients with non-ST-segment elevation myocardial infarction [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 118-122.
[9] QIN Jing, YANG Fei, CHEN Qian, XIA Handai, LIU Yanguo, WANG Xiuwen. A network meta-analysis of first-line treatment options for patients with advanced driver-gene wild-type and PD-L1 negative non-squamous non-small cell lung cancer [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 74-82.
[10] WANG Fuli, SUN Yinping, QIN Jie, RONG Jiansheng. Efficacy of DC-CIK cells combined with EGFR-TKI for 35 elderly patients with advanced EGFR-mutant lung cancer [J]. Journal of Shandong University (Health Sciences), 2022, 60(7): 110-117.
[11] ZHANG Jingliang, LIU Xinyu, YUAN Suomao, WANG Lianlei. Causes of misdiagnosis and mistreatment of lumbar degenerative diseases complicated with hip joint diseases(hip-spine syndrome) [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 67-73.
[12] LI Linlin, WANG Kai. Prediction of hepatocellular carcinoma prognostic genes based on bioinformatics [J]. Journal of Shandong University (Health Sciences), 2022, 60(5): 50-58.
[13] Xianyun LI,Fude YANG. Cognitive behavioral therapy of suicidality [J]. Journal of Shandong University (Health Sciences), 2022, 60(4): 1-9.
[14] SUN Zhenguo, TIAN Hui. Optimization of the procedures in minimally invasive esophagectomy: the Qilu practices [J]. Journal of Shandong University (Health Sciences), 2022, 60(11): 33-37.
[15] ZHU Yongcun, ZHAO Xiushi, SUN Nannan, YAO Zhigang, ZHOU Xingchen, MU Kun. Prostate clear cell adenocarcinomas: a report of 3 cases and literature review [J]. Journal of Shandong University (Health Sciences), 2022, 60(11): 102-107.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] MA Qingyuan, PU Peidong, HAN Fei, WANG Chao, ZHU Zhoujun, WANG Weishan, SHI Chenhui. Effect of miR-27b-3p regulating SMAD1 on osteosarcoma cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 32 -37 .
[2] SUO Dongyang, SHEN Fei, GUO Hao, LIU Lichang, YANG Huimin, YANG Xiangdong. Expression and mechanism of Tim-3 in animal model of drug-induced acute kidney injury[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 1 -6 .
[3] DING Xiangyun, YU Qingmei, ZHANG Wenfang, ZHUANG Yuan, HAO Jing. Correlation of the expression of insulin-like growth factor II in granulosa cells and ovulation induction outcomes of 84 patients with polycystic ovary syndrome[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 60 -66 .
[4] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15 -23 .
[5] LI Ning, LI Juan, XIE Yan, LI Peilong, WANG Yunshan, DU Lutao, WANG Chuanxin. Expression of LncRNA AL109955.1 in 80 cases of colorectal cancer and its effect on cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 38 -46 .
[6] XU Yuxiang, LIU Yudong, ZHANG Peng, DUAN Ruisheng. A retrospective analysis of risk factors of cerebral microbleeds in 101 patients with cerebral small vessel disease[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 67 -71 .
[7] ZHANG Baowen, LEI Xiangli, LI Jinna, LUO Xiangjun, ZOU Rong. miR-21-5p targeted TIMP3 to inhibit proliferation and extracellular matrix accumulation of mesangial cells in Type II diabetic nephropathy mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 7 -14 .
[8] FU Jieqi, ZHANG Man, ZHANG Xiaolu, LI Hui, CHEN Hong. Molecular mechanism of Toll-like receptor 4 in the aggravation of blood lipid accumulation by inhibiting the peroxisome proliferator-activate receptor γ[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 24 -31 .
[9] GUO Zhihua, ZHAO Daqing, XING Yuan, WANG Wei, LIANG Leping, YANG Jing, ZHAO Qianqian. Single-stage end-to-end anastomosis in the management of severe cervical tracheal stenosis[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 72 -76 .
[10] SHI Shuang, LI Juan, MI Qi, WANG Yunshan, DU Lutao, WANG Chuanxin. Construction and application of a miRNAs prognostic risk assessment model of gastric cancer[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 47 -52 .
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd