Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (7): 104-109.doi: 10.6040/j.issn.1671-7554.0.2021.0819

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Ultrasound characteristics and preoperative CA-125 level in the differential diagnosis of 51 cases of borderline ovarian and stage I malignant tumors

ZHANG Yixin, ZHAO Yuli, FENG Li   

  1. Department of Medical Ultrasound, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medical Imaging, Jinan 250014, Shandong, China
  • Published:2022-07-27

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Abstract: Objective To investigate the value of ultrasound characteristics combined with preoperative serum carbohydrate antigen 125(CA-125)levels in the differential diagnosis of borderline ovarian tumors(BOTs)and stage Ⅰ epithelial ovarian cancer(EOC). Methods Clinical data of 27 EOC and 24 BOT pathologically confirmed cases treated during June 2019 and June 2020 were retrospectively analyzed. Independent factors related to ovarian invasion, including clinical variables(menstrual status), ultrasound characteristics and CA-125 level, were analyzed with multivariate binary Logistic regression with stepwise selection of variables. Results Ultrasound findings showed masses with rough edges, ascites, and rich blood flow(blood flow score=4)were indicative of stage Ⅰ EOC, while papillary protrusions and partitions were present in BOT. The ratio of preoperative CA-125 >35 IU/mL or >100 IU/mL in stage Ⅰ EOC was much higher than that in BOT(81.5 vs 41.7%, P=0.003; 40.7 vs 8.3%, P=0.008). The sensitivity and specificity of serum CA-125 level for distinguishing BOT and stage Ⅰ EOC were 81.5% and 58.3%, respectively, indicating that CA-125 level had a certain diagnostic reference value. Multivariate Logistic regression showed that CA-125>100 IU/mL was a key independent factor distinguishing BOT from stage Ⅰ EOC, indicating that patients with CA-125 >100 IU/mL had almost 14.67 times greater likelihood of stage Ⅰ EOC compared patients with CA-125 ≤100 IU/mL(OR=14.67; 95%CI: 1.32-162.94; P=0.029). Conclusion Preoperative CA-125 >100 IU mL combined with ultrasound characteristics helps in the differential diagnosis of borderline ovarian tumor and stage Ⅰ epithelial ovarian cancer before surgery.

Key words: Borderline ovarian tumors, Epithelial ovarian carcinoma, Carbohydrate antigen 125, Ultrasound, Adnexal

CLC Number: 

  • R445.1
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