Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (8): 109-114.doi: 10.6040/j.issn.1671-7554.0.2022.0290

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Mendelian randomization study of sleep phenotypes and irritable bowel syndrome

ZHANG Kai1,2, SI Shucheng1,2, LI Jiqing1,2, LIU Xiaowen1,2, ZHAO Yingqi1,2, XUE Fuzhong1,2   

  1. 1. Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250002, Shandong, China;
    2. Institute for Medical Dataology, Shandong University, Jinan 250012, Shandong, China
  • Published:2022-07-27

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Abstract: Objective To explore the causal relationship between sleep phenotypes and irritable bowel syndrome(IBS). Methods Mutually independent genetic variants closely related to sleep phenotypes were chosen as instrumental variables from the genome-wide association study database(GWAS)and the Finnish Biobank database(FinnGen). With odds ratio(OR)as an outcome indicator, the causal relationship between sleep phenotypes and IBS was analyzed using MR methods, including inverse-variance weighted(MR-IVW), weighted median, simple median method, robust adjusted contour score method, pleiotropic residual sum, and heterogeneity. Results MR-IVW results showed that short sleep duration and insomnia led to an increased risk of IBS by 147%(OR=2.47, 95%CI: 1.13-5.41)and 18% (OR=1.18, 95%CI: 1.14-1.22), respectively. Morning habits were associated with a 12% lower risk of IBS(OR=0.88, 95%CI: 0.84-0.92). The results of external data validation showed that only insomnia was associated with a statistically significant risk of IBS(P<0.001). After relevant covariates were adjusted with multivariate MR methods, the association effect between insomnia and IBS remained statistically significant(P<0.001). Conclusion Short sleep duration and insomnia will increase the risk of IBS.

Key words: Sleep phenotypes, Insomnia, Irritable bowel syndrome, Mendelian randomization, Causal inference

CLC Number: 

  • R714.8
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