JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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GONG Ming-zhi1,ZHANG Li2, XING De-guo1, LIU Zhong-hao1, YIN Zhi-sheng3   

  1. 1. Department of Orthopedics; 2. Department of Electophysiology, the Second Hospital of Shandong University,
  • Received:2005-10-12 Revised:1900-01-01 Online:2006-05-24 Published:2006-05-24
  • Contact: GONG Ming-zhi

Abstract: To observe the changes of behavior functional tests and somatosensory evoked potentials after tractive spinal cord injury (SCI)in rats, and evaluate the influence of sodium aescinate (SA) on spinal cords function. Methods： Eighty Wistar rats were divided into experimental groups and control groups randomly. SA in a dose of 6?mg/kg was intravenously injected into the tail of the experimental rat, and 30 minutes later, whose spinal cord was exposed entirely via dual laminectomy at T10 level and pulled horizontally (displacement of 1.7mm,duration of 5minutes) by a special retractor imitating the neural ecarteur to make the SCI model. The behavior functional tests of hind limbs of rats were evaluated by BBB locomotion scores and inclined plane, and the sensory function ofrats was monitored by cortical somatosensory evoked potential (CSEP) test at different timepoint after SCI. Results：

Key words: Models, animal, Spinal cord injuries, Evoked potentials, somatosensory, Saponins, Rats, Wistar

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