Journal of Shandong University (Health Sciences) ›› 2022, Vol. 60 ›› Issue (3): 45-50.doi: 10.6040/j.issn.1671-7554.0.2021.1149

Previous Articles    

Clinical and imaging features of 19 cases of anti-myelin oligodendrocyte glycoprotein-IgG antibody associated disorders

FENG Baomin1, WANG Zhou2, XU Han1, LI Jiacun1, YU Qiaowen1, XIU Jianjun1   

  1. 1. Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    2. Department of Radiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China
  • Published:2022-03-09

PDF (PC)

244

Abstract: Objective To investigate the clinical and imaging features of anti-myelin oligodendrocyte glycoprotein-IgG antibody associated disorders(MOGAD). Methods The clinical and imaging data of 19 MOGAD patients confirmed in Shandong Provincial Hospital Affiliated to Shandong First Medical University during Sep. 2018 and Jun. 2021 were retrospectively analyzed. Results The patients included 9 males and 10 females, with a median age of 10 years. Seven cases manifested asaquaporin4(AQP4)negative neuromyelitis optica spectrum disorder(NMOSD); 6 cases presented with acute disseminated encephalomyelitis(ADEM); 4 cases presented with encephalitis, 1 of which complicated with anti-N-methyld-aspartate receptor(NMDAR)encephalitis; 1 case presented with transverse myelitis; 1 case presented with brainstem encephalitis. Abnormal signals were detected with brain MRI in 17 cases(17/19), and the lesions could be involved in any part of the brain, presenting multifocal ill-defined T2WI hyperintensity. Spinal MRI found abnormal signals in 4 cases(4/13). Orbital MRI detected abnormal signals in 4 cases(4/9), presenting T2WI hyperintensity in optic nerves, 2 of which(2/4)showed optic crossover and optic tract. The serum MOG-IgG antibody of all patients was positive; 1 case was NMDAR antibody positive; 1 case was thyroidperoxidase antibody positive. Conclusion The MOGAD clinical phenotype is associated with age, more common in children and adolescents, and prone to relapse. Lesions can involve the optic nerves, spinal cord, intracranial and other parts. The imaging performance is varied.

Key words: Myelin oligodendrocyte glycoprotein antibody, Neuromyelitis optica spectrum disorder, Multiple sclerosis, Magnetic resonance imaging

CLC Number: 

  • R445.2
[1] Wynford-Thomas R, Jacob A, Tomassini V. Neurological update: MOG antibody disease [J]. J Neurol, 2019, 266(5): 1280-1286.
[2] 中国免疫学会神经免疫分会. 抗髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体相关疾病诊断和治疗中国专家共识[J]. 中国神经免疫学和神经病学杂志, 2020, 27(2): 86-95.
[3] Linington C, Morgan BP, Scolding NJ, et al. The role of complement in the pathogenesis of experimental allergic encephalomyelitis [J]. Brain, 1989, 112(Pt 4): 895-911.
[4] Cobo-Calvo A, Ruiz A, Maillart E, et al. Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study [J]. Neurology, 2018, 90(21): e1858-e1869.
[5] Akaishi T, Nakashima I, Takeshita T, et al. Different etiologies and prognoses of optic neuritis in demyelinating diseases [J]. J Neuroimmunol, 2016, 299: 152-157. doi: 10.1016/j.jneuroim.2016.09.007.
[6] Jarius S, Paul F, Aktas O, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing [J]. J Neuroinflammation, 2018, 15(1): 134. doi:10.1186/s12974-018-1144-2.
[7] Dale RC, Tantsis EM, Merheb V, et al. Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton [J]. Neurol Neuroimmunol Neuroinflamm, 2014, 1(1): e12. doi:10.1212/NXI.0000000000000012.
[8] Reindl M, Waters P. Myelin oligodendrocyte glycoprotein antibodies in neurological disease [J]. Nat Rev Neurol, 2019, 15(2): 89-102.
[9] Jurynczyk M, Messina S, Woodhall MR, et al. Clinical presentation and prognosis in MOG-antibody disease: a UK study [J]. Brain, 2017, 140(12): 3128-3138.
[10] Cole J, Evans E, Mwangi M, et al. Acute disseminated encephalomyelitis in children: an updated review based on current diagnostic criteria [J]. Pediatr Neurol, 2019, 100: 26-34. doi: 10.1016/j.pediatrneurol.2019.06.017.
[11] 李波, 陈中婕, 奚玲如,等. 成人MOG抗体相关性脑脊髓炎患者15例临床特点分析[J]. 新医学, 2021, 52(1): 6. LI Bo, CHEN Zhongjie, XI Lingru, et al. Clinical characteristics of 15 adult cases of MOG-IgG-associated encephalomyelitis [J]. Journal of New Medicine, 2021, 52(1): 6.
[12] 李波, 王展航, 潘梦秋, 等. 儿童MOG抗体阳性的中枢神经系统脱髓鞘病变12例临床特点分析[J]. 中国神经免疫学和神经病学杂志, 2020, 27(1): 40-45. LI Bo, WANG Zhanhang, PAN Mengqiu, et al. Clinical characteristics of 12 cases of children with MOG-IgG associated central nervous system demyelination [J]. Chin J Neuroimmunol&Neurol, 2020, 27(1): 40-45.
[13] Sepúlveda M, Armangue T, Martinez-Hernandez E, et al. Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes [J]. J Neurol, 2016, 263(7): 1349-1360.
[14] Kim HJ, Paul F, Lana-Peixoto MA, et al. MRI characteristics of neuromyelitis optica spectrum disorder: an international update [J]. Neurology, 2015, 84(11): 1165-1173.
[15] Jarius S, Ruprecht K, Kleiter I, et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin [J]. J Neuroinflammation, 2016, 13(1): 279. doi:10.1186/s12974-016-0717-1.
[16] Dubey D, Pittock SJ, Krecke KN, et al. Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody [J]. JAMA Neurol, 2019, 76(3):301-309.
[17] Sato DK, Callegaro D, Lana-Peixoto MA, et al. Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders [J]. Neurology, 2014, 82(6):474-481.
[18] Geraldes R, Ciccarelli O, Barkhof F, et al. The current role of MRI in differentiating multiple sclerosis from its imaging mimics [J]. Nat Rev Neurol, 2018, 14(4): 199-213.
[19] Cobo-Calvo A, Vukusic S, Marignier R. Clinical spectrum of central nervous system myelin oligodendrocyte glycoprotein autoimmunity in adults [J]. Curr Opin Neurol, 2019, 32(3): 459-466.
[20] Carra-Dalliere C, Menjot de Champfleur N, Ayrignac X, et al. Optic chiasm and oculomotor nerves involvement in active multiple sclerosis [J]. J Neuroradiol, 2020, 47(1): 62-64.
[1] LIU Xueye, LI Qiming, TANG Hongyi, XU Qiuping, CHEN Wenqian, GUO Jing. Relationship among the volume and surface area of the temporomandibular joint condyle and the sagittal position of disc in young adults [J]. Journal of Shandong University (Health Sciences), 2021, 59(6): 117-121.
[2] ZHANG Gaorui, ZHANG Yuting, ZHAO Yuxuan, WANG Fangqing, YU Dexin. Value of MnFe2O4@CNS in the theragnostic of pancreatic cancer [J]. Journal of Shandong University (Health Sciences), 2021, 59(4): 48-55.
[3] SUN Dingqi, FU Qiang, ZHANG Hui, LIU Shuai, DIAO Tongxiang, CAO Qingwei, ZHANG Keqin. Clinical value of targeted multiparameter MRI and transrectal ultrasonography fusion prostate biopsy for the detection of PI-RADS≥3 prostate cancer [J]. Journal of Shandong University (Health Sciences), 2021, 59(4): 108-113.
[4] SONG Zhenzhen, SUN Xiaoling, LI Haiou, WANG Fang, ZHANG Ran, YU Dexin. Value of MRI radiomics of glioma and peritumoral edema in evaluating tumor recurrence [J]. Journal of Shandong University (Health Sciences), 2021, 59(11): 53-60.
[5] CHEN Xiaoli, GUI Zhenchao, GAO Yang, XING Mengyao, XIU Jianjun. Imaging findings of 13 cases of salivary duct carcinoma [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 78-82.
[6] WANG Yuhong, ZHANG Lihong, WANG Linsheng, CHEN Yueqin, WANG Yanhui, WANG Jiehuan, LI Chuanfu. Imaging features of granular cell tumor in the alimentary system [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(8): 66-70.
[7] XU Yujun, LIU Ming, HE Xiangmeng, LI Chengli. 1.0T open MRI-guided 125I seeds percutaneous implantation for advanced pancreatic cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(2): 21-25.
[8] WANG Guangbin. Magnetic resonance imaging in the evaluation of pernicious placenta previa [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(9): 7-9.
[9] SHA Sha, Chowdhury Sumon Rahman, CHEN Li, HE Qin, ZHANG Jing, FAN Shanshan, SUN Lei. Effect of liraglutide on leptin and fat content in high fat diet induced obese mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 22-27.
[10] GAO Meng, SUN Jianmin, JIANG Zhensong, CUI Xingang. Diagnostic value of MRI for brucellar spondylitis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 27-30.
[11] DONG Jinye, LIN Xiangtao, CAO Jinfeng, WU Yong, ZHAO Hui, XIE Huihui, XIAO Lianxiang. Fetal cervical enlargement development between 16 and 42 weeks of gestational age: a postmortem MRI study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 74-78.
[12] ZHANG Zhan, XU Xiangfeng, LIU Haidong, WANG Wei. Diagnostic value of MRI in the T-staging of cervical cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(5): 70-73.
[13] DIAO Xiaojun, CHEN Chunfu, LI Congcong, ZHANG Yingbo, LI Yingying. Characteristics and prevalence of primary headaches in patients with multiple sclerosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 42-45.
[14] BAO Hongjing, WANG Guangbin, WANG Shanshan, WU Chao. Diffusion-weighted MR neurography of the median nerve in carpal tunnel syndrome: a preliminary study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 72-75.
[15] MENG Xiangshui, CHAI Xiangjun, MA Xiangxing, REN Qingguo, YANG Zhicheng. Value of CT and MRI in the treatment options of laryngeal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 76-79.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd