Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (10): 82-88.doi: 10.6040/j.issn.1671-7554.0.2021.0456

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Efficacy of SEEG-guided radiofrequency thermocoagulation in patients with medically intractable epilepsy

JIA Jianhua, CHEN Si, WU Qianqian, XU Shuo, LI Chao, CHENG Lian, XU Shujun   

  1. Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Published:2021-10-15

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Abstract: Objective To analyze the efficacy of radiofrequency thermocoagulation(RF-TC)guided by stereoelectroencephalography(SEEG)in patients with medically intractable epilepsy. Methods A total of 14 patients treated in our hospital during Nov. 2018 and Nov. 2020 were enrolled. Epileptogenic zones were located with SEEG, and RF-TC was performed on the epileptogenic zones. The efficacy and safety were evaluated. Results Altogether 143 electrodes were implanted, and 50 electrodes were radiofrequency thermocoagulated according to the SEEG localization results. Patients were followed up for 2 to 25 months after treatment, with a mean of(8.29±7.90)months. Two cases(14.30%)were followed up for 3 and 6 months respectively, seizure-free, classified as Engel Ⅰ; 4 cases(28.57%)were followed up with a mean of(3.75±0.50)months, and their seizures decreased by more than 90%, classified as Engel Ⅱ; 5 cases(35.71%)were followed up for a mean of(8.00±6.32)months, and their seizures decreased by more than 50%, classified as Engel Ⅲ; 2 cases(14.30%)were followed up for 25 months, and their seizures decreased by less than 50%; 1 case(7.10%)was followed up for 2 months, and the seizure was the same as that before treatment, classified as Engel Ⅳ. There was statistical significance in the frequency of seizure before and after thermocoagulation in all cases(P=0.0017), and the efficacy of thermocoagulation declined with time. No permanent functional impairment was observed. Conclusion SEEG-guided radiofrequency thermocoagulation is a safe and effective treatment for medically intractable epilepsy, but there are many factors that affect its efficacy. It can effectively predict the curative effect of surgical resection and can be used as the main treatment option for specific types of epileptic lesions.

Key words: Stereoelectroencephalography, Radiofrequency thermocoagulation, Intractable epilepsy, Efficacy

CLC Number: 

  • R742.1
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