Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (5): 81-84.doi: 10.6040/j.issn.1671-7554.0.2018.210

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Safety and efficacy of single dose rituximab in primary immune thrombocytopenia

NIE Mu, NI Xiaofei, QIN Ping, YANG Dandan, LI Qiang, HOU Ming, PENG Jun, ZHANG Xiaolin, SHI Yan   

  1. Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2018-02-09 Published:2022-09-27

Abstract: Objective To investigate the activity, safety and response duration of single dose rituximab(RTX)in previously treated primary immune thrombocytopenia(ITP). Methods Thirty patients with ITP who had failed to respond to glucocorticosteroids were treated with a single dosage of 500 mg rituximab in Department of Hematology, Qilu Hospital of Shandong University. The clinical effect, onset time, duration of efficacy and adverse reactions were observed. Results Response and complete response were achieved in 9(30.00%)and 13(43.33%)patients, respectively. In responders, the median time to response was 30 days(range: 7-60 d). Sustained response was maintained for over 12 months in 68.18%(15/22)patients with the shortest sustained response time of 3 months. No serious infectious, hematologic or extra-hematologic complications were documented during follow-up. Conclusion The single dose of 500 mg rituximab may be effective and safe for corticosteroid-resistant or relapsed patients with ITP.

Key words: Immune thrombocytopenia, Rituximab, Efficacy

CLC Number: 

  • R574
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