JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2017, Vol. 55 ›› Issue (9): 36-40.doi: 10.6040/j.issn.1671-7554.0.2017.072

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Expressions of PARP-1 and EMT markers in eutopic and ectopic endometrium of adenomyosis

LIN Xueyan, LI Chunyan, HOU Xiaoman, TIAN Yongjie   

  1. Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2017-01-18 Online:2017-09-10 Published:2017-09-10

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Abstract: Objective To detect the expression of poly(ADP-ribose)polymerase-1(PARP-1)in eutopic and ectopic endometrium of women with adenomyosis and to investigate the correlation between PARP-1 and epithelial-mesenchymal transition(EMT)markers in eutopic and ectopic endometrium of women with adenomyosis. Methods The expressions of PARP-1 and EMT markers, including E-cadherin, vimentin and Snail, were detected by immunohistochemistry in eutopic and ectopic endometrium of women with adenomyosis and in eutopic endometrium of women without adenomyosis. The correlation between PARP-1, E-cadherin, vimentin and Snail expression levels were analyzed by Spearman correlation analysis. Results The expressions of PARP-1, vimentin and Snail in eutopic and ectopic endometrium with adenomyosis were significantly higher than those in the normal endometrium with adenomyosis(all P<0.05). The expression of E-cadherin in eutopic and ectopic endometrium with adenomyosis were significantly lower than that in the normal endometrium(all P<0.05). In the lesions of the eutopic and ectopic endometrium with adenomyosis, the expression level of PARP-1 was negatively correlated with E-cadherin, while positively correlated with vimentin and Snail. Conclusion PARP-1 is highly expressed in eutopic and ectopic endometrium of women with adenomyosis and is related with EMT markers. PARP-1 may be involved in the EMT process of adenomyosis.

Key words: Adenomyosis, Snail, Epithial-mesenchymal transition, Poly(ADP-ribose)polymerase-1, E-cadherin, Vimentin

CLC Number: 

  • R711.71
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