JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (9): 30-33.doi: 10.6040/j.issn.1671-7554.0.2014.166

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Effect of panax quinquefolium saponin from stems and leaves on endothelin-1, vascular endothelial growth factor and infarct area in rats

FU Qingyuan1, DAI Guiqiang1, ZHANG Song2, AN Hongchun3, LIANG Shimin1   

  1. 1. Department of Emergency, the 5th People's Hospital of Jinan, Jinan 250022, Shandong, China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of Neurology, the 1th People's Hospital of Jinan, Jinan 250011, Shandong, China
  • Received:2014-03-23 Revised:2014-08-29 Online:2014-09-10 Published:2014-09-10
  • Contact: 付庆元。E-mail:fqy132@163.com E-mail:fqy132@163.com

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Abstract: Objective To explore the effect of panax quinquefolium saponin (PQS) from stems and leaves on endothelin-1 (ET-1), vascular endothelial growth factor (VEGF) and cerebral infarct area in rats. Methods Rats were randomly divided into sham operation group, model control group, nimodipine group, high doses of PQS group and low doses of PQS group, after the right cerebral arteries were bolted to induce embolization. The neurological deficit, ET-1 and VEGF levels, and infarct area in each group were detected and compared. Results The neurological function recovered better in high and low doses of PQS groups than in other groups (P<0.05). Compared with the model control group, the other groups had significantly declined ET-1 expressions (P<0.05), and there was statistical difference between any two groups (P<0.05). The high doses of PQS group had the highest VEGF expression but the least infarct area compared with the other groups. Conclusion Panax quinquefolium saponin from stems and leaves has a significant effect to enhance vascular activity and thus relieve cerebral infarction.

Key words: Endothelin-1, Panax quinquefolium saponin from steams and leaves, Vascular endothelial growth factor, Infarct area

CLC Number: 

  • R743.32
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