JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Correlation among Ki-67, PTTG, VEGF and pituitary apoplexy

ZHAO Hua1, XU Yangyang2, LU Xiangdong3， XU Tongjiang1   

  1. 1. Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University,
    Jinan 250021, Shandong，  China;
    2. Clinical Medicine (Five-Year), School of Medicine, Shandong University, Jinan 250012, Shandong， China;
    3. Department of Neurosurgery, People's Hospital of Laiwu City, Laiwu 271100, Shandong， China
  • Received:2013-11-20 Online:2014-05-10 Published:2014-05-10

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Abstract: Objective  To explore the expressions and significance of Ki-67, PTTG and VEGF in pituitary apoplexy. Methods  A total of 60 cases of pituitary adenoma, including 28 cases of apoplexy adenoma (apoplexy group) and 32 cases of non-apoplexy pituitary adenoma (non-apoplexy group) were collected. Expressions of Ki-67, PTTG and VEGF were analyzed with immunohistochemical method and Western blotting. Results  The Ki-67 expression was significantly higher in the apoplexy group than in the non-apoplexy group (P<0.05); however, there was no significant difference in the PTTG and VEGF expressions between the two groups (P>0.05). Conclusion  Cell proliferation in pituitary apoplexy is significantly higher than in non-apoplexy pituitary, while PTTG and VEGF have the same ability to induce the blood vessel.

Key words: Nuclear- associated antigen Ki- 67, Vascular endothelial growth factor, Pituitary apoplexy, Pituitary tumor transforming gene, Immunohistochemical, Western blotting

CLC Number: 

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