JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (7): 56-59.doi: 10.6040/j.issn.1671-7554.0.2013.760

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Expression and clinical-pathological significance of NRP2 in gastric carcinoma

LIAN Haifeng1, LI Ming2, LIU Chengxia1, JIA Xingfang1, LI Dan3   

  1. 1. Department of Gastroenterology, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China;
    2. Department of Gastroenterology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264117, Shandong, China;
    3. School of Nursing, Binzhou Medical University, Binzhou 256603, Shandong, China
  • Received:2013-12-19 Revised:2014-06-12 Online:2014-07-10 Published:2014-07-10

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Abstract: Objective To explore the expression and clinical significance of neuropilin-2 (NRP2) in gastric carcinoma (GC). Methods A total of 65 gastric carcinoma and adjacent non-tumorous specimens were collected. NRP2 protein and mRNA were detected with quantitative real time PCR (qRT-PCR) and Western blotting, and clinicopathological parameters of gastric carcinoma were analyzed. Results There was a significantly higher expression of NRP2 in GC tissues compared with in adjacent non-tumorous tissues in both gene and protein levels (P<0.05). Statistical analysis revealed that NRP2 expression in GC tissues was positively correlated with tumor size, lymph node metastasis, depth of infiltration, TNM stage and distant metastasis, but not with gender, age and histological classification (P>0.05). Conclusion NRP2 expression is up-regulated in gastric carcinoma and may play important roles in the metastasis and development of gastric carcinoma, which suggests NRP2 may be a potential target of therapy for GC.

Key words: Neuropilin-2, Clinicopathological parameters, Stomach neoplasm, Western blotting

CLC Number: 

  • R574
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