JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Correlation between airway inflammation and asthma marine remodeling and corticosteroid resistence in rats with respiratory syncial virus infection

YANG Yan-na1，CHEN Fang-fang2，LI Wei1，WANG Yan1， WANG Xing-guang1，JIANG Shu-juan1   

  1. Department of Respiratory, 1. Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 2. Shandong Qianfoshan Hospital， Jinan 250014, China
  • Received:2007-11-22 Revised:1900-01-01 Online:2008-04-16 Published:2008-04-16
  • Contact: JIANG Shu-juan

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Abstract: To explore the relationship of airway inflammation and murine model to corticosteroid resistance after respiratory syncytial virus (RSV) infection. Methods 50 BALB/c mice were divided into 5 groups: the control group, the OVA group（group A）, the OVA+Dex group（group B）, the OVA/RSV group(group C), and the OVA/RSV+ Dex group（group D）, 10 mice in each group. Then the concentrations of the interleukin 4（IL-4）, interleukin 5（IL-5）, interferon-γ（IFN-γ）and transforming growth factor-β1(TGF-β1) were determined by ELISA. Pathological slides were stained with hematoxylineosin and Van. Gieson, and degree of the peribronchial inflammation and airway collage deposition were observed. ResultsCompared with the control group, concentrations of IL-4, IL-5 and TGF-β1 were significantly increased in groups A, C and D and airway inflammation and collagen deposition were also aggravated（P＜0.05）. Also concentrations of IL-4, IL-5 and TGF-β1 and airway inflammation and remodeling were gradually increased in the given order of groups A, C and D（P＜0.05）. Conclusion RSV infection results in a significant Th2 inflammation and airway remodeling in rats with asthma, and the rats are not sensitive to corticosteroid treatment.

Key words: Model, asthma, Respiratory syncytial virus, Inflammatory mediaters, Collagen deposition

CLC Number: 

  • R562.2
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