Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (6): 100-106.doi: 10.6040/j.issn.1671-7554.0.2025.0216

• Clinical Medicine • Previous Articles    

Influence of physiological indicators on parathyroid gland function

LIU Kailin1*, GUO Ying1*, WANG Zhihao1, GENG Chong1, WANG Nana2   

  1. 1. Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China;
    2. Second Department of Breast Diseases, Second Department of Thyroid Diseases, Shandong Second Provincial General Hospital, Jinan 250022, Shandong, China
  • Published:2025-07-08

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Abstract: Objective To analyze the influence of various basic physiological indicators on parathyroid hormone(PTH)levels and explore their roles in the regulation of PTH metabolism. Methods A retrospective analysis was conducted on the clinical data of 1,391 hospitalized patients from October 2023 to October 2024. Spearman correlation analysis and stepwise multiple linear regression were employed to identify the major determinants of serum PTH levels. Additionally, data from 2,034 and 311 patients between January 2022 and November 2024 were retrospectively analyzed to investigate the impact of seasonal variation on PTH and 25-hydroxyvitamin D ［25(OH)D］ levels, respectively. Results Multiple linear regression analysis indicated that BMI(β=0.157, P<0.001), albumin(ALB)(β=0.095, P=0.001), and free fatty acids(FFA)(β=0.177, P<0.001)were positively associated with serum PTH levels, whereas retinol-binding protein(RBP)(β=-0.056, P=0.048)and Ca2+(β=-0.309, P<0.001)were negatively associated with PTH levels. Additionally, serum PTH and 25(OH)D levels exhibited seasonal variations, with PTH levels being lower in March and from August to September, peaking in May. Meanwhile, 25(OH)D levels remained higher from July to October. No significant gender differences in PTH levels were observed. Conclusion Serum PTH levels are positively correlated with BMI, ALB, and FFA, and negatively correlated with RBP and Ca2+. In addition, gender differences have no effect on PTH levels. PTH levels exhibit an overall inverse trend with 25(OH)D levels, suggesting that metabolic factors and seasonal variations may play an important role in the regulation of PTH.

Key words: Parathyroid hormone, Body mass index, Retinol-binding protein, Blood glucose, 25-hydroxyvitamin D

CLC Number: 

  • R582
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