Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (8): 61-66.doi: 10.6040/j.issn.1671-7554.0.2021.0708

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A comparative analysis of the effects of natural cycle combined with luteal ovarian stimulation and dual ovarian stimulation

CHEN Wei, GUO Qingqing, XU Jin, FANG Yuan, SUN Mei, SHENG Yan   

  1. Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250001, Shandong, China
  • Published:2021-09-16

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Abstract: Objective To compare the pregnancy outcome and cost-effectiveness of nature cycle with luteal phase stimulation(NLPS)and dual ovarian stimulation(DuoS). Methods A total of 376 cycles in 356 patients were enrolled in this retrospective cohort study, including 137 cycles using NLPS and 239 cycles using DuoS protocols. Basic characteristics of patients, treatment variables, outcomes, average cost per cycle, and the cost-effectiveness for one good quality embryo were compared between the two groups. The luteal phase and follicular phase outcomes and cost-effectiveness ratio were also compared. Results There were no differences between NLPS and DuoS groups in the numbers of oocyte retrieval(P=0.41), two pronuclei(2PN)(P=0.74), good quality embryos(P=0.10), and the rate of clinical pregnancy(P=0.08). The cost per cycle was lower in NLPS(P<0.01), but the cost-effectiveness for one good quality embryo was better in DuoS. The numbers of oocyte retrieval, 2PN, and good quality embryos were higher after LPS(3.47±4.26 vs 1.13±1.21, Z=-8.59, P<0.01; 2.03±2.59 vs 0.62±0.87, Z=-7.77, P<0.01; 0.80±1.27 vs 0.24±0.50, Z=-6.52, P<0.01). The cost per cycle was higher in LPS, but the cost-effectiveness was also better(P<0.01). Conclusion NLPS shows same clinical outcome compared with DuoS, but has lower cost per cycle. DuoS has better cost-effective to obtain one good quality embryo. LPS contributes more to the final outcome and is more economical compared to follicular phase stimulation within the same cycle.

Key words: Luteal phase stimulation, Dual ovarian stimulation, In vitro fertilization, Clinical pregnancy, Cost-effectiveness

CLC Number: 

  • R711.6
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