Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 1-7.doi: 10.6040/j.issn.1671-7554.0.2017.1293

   

Clinical research advances on premature ovarian insufficiency

CHEN Shiling, ZHOU Xingyu   

  1. Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China)〓山〓东〓大〓学〓学〓报〓(医〓学〓版)56卷4期〓-陈士岭, 等.早发性卵巢功能不全的临床诊治进展〓\=-〓〓
  • Published:2022-09-27

Abstract: Premature ovarian insufficiency(POI)is a clinical syndrome manifested with significant decline or loss of ovarian activity before the age of 40 years, which has serious effects on the reproductive, physical and mental health of women. The causes of POI are involved with genetic factors, immunological factors and iatrogenic factors, and the etiology of most patients remains unclear. The fertility of POI patients dramatically decreases, but there is no satisfactory treatment so far. Hormone replacement therapy(HRT)is considered an effectively preventative and therapeutic option to manage complications related to POI. Although many researchers have focused on the mechanism, diagnosis and treatment of POI in recent years, much remains to be explored. This article will review the clinical research advances on POI.

Key words: Premature ovarian insufficiency, In vitro fertilization-embryo transfer, Hormone replacement therapy, Fertility preservation

CLC Number: 

  • R711.75
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