Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (9): 54-58.doi: 10.6040/j.issn.1671-7554.0.2018.516

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Clinical outcomes of IVF/ICSI-ET after thyroid cancer surgical treatment

YU Na, GUO Qingqing, SUN Mei, SHENG Yan, MA Zengxiang, QIN Yingying   

  1. Center for Reproductive Medicine, Shandong University;
    National Research Center for Assisted Reproductive Technology and Reproductive Genetics;
    Key Laboratory of Reproductive Endocrinology(Shandong University), Ministry of Education;
    Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan 250001, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To investigate the effect of thyroid carcinoma on the pregnancy outcomes, obstetric and neonatal complications during in vitro fertilization/follicle intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET)treatment. Methods Forty-two patients who underwent IVF/ICSI-ET after thyroid cancer surgery from January 1, 2012 to December 31, 2016 were retrospectively analyzed. Ninety patients with normal thyroid hormone level and thyroid ultrasound images were included as control group. The total amount of Gn, endometrial thickness on HCG day, and the number of retrieved oocytes were compared between cases and controls. The normal fertilization rate, good quality embryo rate, implantation rate, clinical pregnancy rate, miscarriage rate, live birth rate, and maternal and neonatal complications were also compared. Results The level of serum thyroid stimulating hormone(TSH)was significantly lower in cases than controls ［(1.70±1.50)μIU/mL vs(2.20±0.84)μIU/mL, P<0.05］. The total Gn ［(2 048.22± 山 东 大 学 学 报 (医 学 版)56卷9期 -于娜,等. 甲状腺癌术后行IVF/ICSI-ET助孕临床结局 \=-774.40)U vs(1 867.64±899.79)U］, endometrial thickness on HCG day ［(1.08±0.16)cm vs(1.10±0.17)cm］, number of oocytes ［(12.19±7.91)vs (10.92±4.65)］, normal fertilization rate(57.30% vs 58.09%)and good quality embryo rate(61.38% vs 65.10%)were comparable between cases and controls. No difference was observed in the clinical pregnancy rate(61.11% vs 61.67%), implantation rate(41.43% vs 43.14%), abortion rate(9.09% vs 10.81%), and live birth rate(55.55% vs 50.0%). The incidence of obstetric complications(25.0% vs 6.45%)and birth weight of newborns ［(3.21±0.63)kg vs (3.10±0.56)kg］ were not statistically different(P>0.05). One baby from case group was diagnosed with neonatal hypothyroidism. There was no recurrence of thyroid carcinoma during IVF/ICSI-ET treatment. Conclusion Compared with controls, patients with history of thyroid cancer surgery present normal ovarian response and pregnancy outcomes undergoing IVF/ICSI-ET treatment. However, more attention is needed for neonatal hypothyroidism after maternal thyroid surgery.

Key words: In vitro fertilization/follicle intracytoplasmic sperm injection-embryo transfer, Thyroid cancer, Thyroid-stimulating hormone, Gestational diabetes, Neonatal hypothyroidism

CLC Number: 

  • R711.6
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