Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (1): 59-63.doi: 10.6040/j.issn.1671-7554.0.2020.0742

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Analysis of clinical characteristics of 48 cases of gallbladder adenoma based on different pathological grades

LIANG Li, SUN Bin, ZHANG Hongzhan, YE Fangzhi, FENG Xianguang, ZHANG Kai   

  1. Department of Hepatobiliary Surgery, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250031, Shandong, China
  • Published:2021-01-09

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Abstract: Objective To investigate the clinical characteristics and canceration risks of gallbladder adenoma with different pathological grades. Methods The clinical data of 48 cases of gallbladder adenoma were retrospectively analyzed. The patients were divided into different groups according to the pathological grades and canceration risks. Gender, age, associated clinical symptoms, complicated gallstones, single polyp, polyp size, CEA and CA199 were analyzed. Results According to the pathological grades, the patients were divided into 3 groups: simple gallbladder adenoma group(n=24, 50%), gallbladder adenoma with low-grade intraepithelial neoplasia group(n=17, 35.4%), and gallbladder adenoma with high-grade intraepithelial neoplasia group(n=7, 14.6%), which included 2 cases of intramucosal focal carcinoma. The incidence of gallbladder adenoma with intraepithelial neoplasia was 50%, and the overall cancerization rate was 4.2%(2/48). Among the clinical characteristics, age, associated clinical symptoms and polyp size showed significant statistical differences among gallbladder adenoma with different pathological grades(P<0.05). There were significant statistical differences in age, associated clinical symptoms and polyp size between the simple gallbladder adenoma group and intraepithelial neoplasia groups(P<0.05). According to binary Logistic regression analysis, age(OR=5.716, 95%CI: 1.387-23.564)and polyp size(OR=4.442, 95%CI: 1.057-18.675)were the risk factors of canceration. Conclusion Half of gallbladder adenomas are complicated with different grades of intraepithelial neoplasia, with a certain malignant potential.

Key words: Gallbladder adenoma, Intraepithelial neoplasia, Gallbladder cancer, Clinical analysis

CLC Number: 

  • R657.4
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