Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (6): 53-59.doi: 10.6040/j.issn.1671-7554.0.2020.112

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Correlation between thyroid hormonal levels and clinical characteristics of 142 women with breast cancer

GUO Tian1*, FU Yilin1*, GAO Ling1, SONG Yongfeng1, FU Guobin2, GENG Chong3, WANG Weibo2   

  1. 1. Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Jinan 250021, Shandong, China;
    2. Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    3. Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the relationship between clinical characteristics of female breast cancer and thyroid hormonal levels. Methods The clinical data of 142 female breast cancer patients were collected, including basic characteristics, tumor characteristics, thyroid function, and so on. The patients were classified into different groups according to age, menstrual status, tumor size, degree of metastasis, TNM stage, pathological grade, estrogen receptor, diabetes, surgery, chemotherapy and tumor markers. The differences in thyroid hormonal levels were statistically analyzed among the groups. Results (1) There was statistically significant difference in free triiodothyronine(FT3)level among the non-metastasis group, local lymph node metastasis group and distant metastasis group(F=11.565, P<0.001). The distant metastasis group had higher FT3 level than non-metastasis group ［(5.10±0.51)vs(4.67±0.45)pmol/L, P<0.001］ and local lymph node metastasis group ［(5.10±0.51)vs(4.58±0.49)pmol/L, P<0.001］. There was statistically significant difference in free thyroxine(FT4)level among the three groups(F=5.730, P<0.05). The non-metastasis group had higher FT4 level than local lymph node metastasis group ［(16.77±2.59)vs(15.26±2.15)pmol/L, P=0.001］ and distant metastasis group ［(16.77±2.59)vs(15.75±2.08)pmol/L, P=0.053］. When age, menstrual status, estrogen receptor, diabetes, surgery and chemotherapy were taken as covariates, there was significant difference in FT3 level among the three groups(F=6.810, P<0.05). The distant metastasis group had higher FT3 level than local lymph node metastasis group ［(5.10±0.12)vs(4.58±0.07)pmol/L, P<0.001］ and non-metastasis group ［(5.10±0.12)vs(4.67±0.06)pmol/L, P<0.001］, and local lymph node metastasis group had lower FT3 level than non-metastasis group ［(4.58±0.07)vs(4.67±0.06)pmol/L, P<0.001］. The was significant difference in FT4 level among the three groups(F=3.855, P<0.05). The local lymph node metastasis group had lower FT4 level than non-metastasis group ［(15.25±0.37)vs(16.52±0.32)pmol/L, P<0.001］ and distant metastasis group ［(15.25±0.37)vs )16.34±0.60)pmol/L, P<0.001］. (2) The surgical group had higher FT3 level than non-surgical group ［(4.86±0.59)vs(4.66±0.44)pmol/L, t=2.354, P<0.05］. (3) The chemotherapy group had higher FT3 level than non-chemotherapy group ［(4.95±0.50)vs(4.62±0.48)pmol/L, t=3.862, P<0.001］, but lower FT4 level ［(15.38±2.02)vs(16.49±2.57)pmol/L, t=-2.593, P<0.05］. Conclusion Thyroid hormones are associated with the metastasis of breast cancer. Both surgery and chemotherapy may affect the levels of thyroid hormones.

Key words: Thyroid hormones, Breast cancer, Metastasis, Triiodothyronine, Chemotherapy

CLC Number: 

  • R574
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