JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (5): 45-49.doi: 10.6040/j.issn.1671-7554.0.2016.020

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Expression and significance of ER and PR in fibroids and myometrium during pregnancy

LIU Ran1, TAO Guowei2, ZHEN Junhui3, LUO Xia1, QIAN Richeng4   

  1. 1. Department of Obstetrics and Gynecology;
    2. Department of Ultrasonography;
    3. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2016-01-06 Online:2016-05-16 Published:2016-05-16

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Abstract: Objective To explore the expression and significance of ER and PR in fibroids and myometrium during pregnancy. Methods (1) We collected 9 pregnant womens fibroids(group A)and myometrium(group B), and 12 non-pregnant womens fibroids(group C)and myometrium(group D). The expressions of ER and PR in these tissues were detected with immunohistochemistry. (2) We selected 110 pregnant women with fibroids as the research objects, and recorded the sizes of fibroids through ultrasonic reports in early pregnancy(less than 13 weeks), mid pregnancy(16 to 23 weeks gestation)and late pregnancy(37 to 40 weeks gestation). Results (1) The expressions of ER in group A and B were negative. The expression of PR in group A was significantly higher than that in group B(P=0.033). The expressions of ER and PR in group A were significantly lower than those in group C(P=0.000, P=0.001). (2) There was no significant difference in the sizes of fibroids between early mid and late pregnancy(P=0.741). But fibroids had an 山 东 大 学 学 报 (医 学 版)54卷5期 -刘冉,等.ER、PR在妊娠期子宫肌瘤组织中的表达及意义 \=-increasing trend in early and mid pregnancy and had a decreasing trend in late pregnancy. Conclusion ER and PR may play an important role in the growth of fibroids during pregnancy. However, whether ER deletion is related to the slow growth of fibroids with high estrogen and progesterone during pregnancy still remains unclear.

Key words: Progesterone receptor, Pregnancy, Uterine fibroids, Estrogen receptor

CLC Number: 

  • R714.2
[1] Al-Hendy A, Diamond MP, El-Sohemy A, et al. 1,25-dihydroxyvitamin D3 regulates expression of sex steroid receptors in human uterine fibroid cells[J]. J Clin Endocrinol Metab, 2015, 100(4): E572-582.
[2] Eze CU, Odumeru EA, Ochie K, et al. Sonographic assessment of pregnancy co-existing with uterine leiomyoma in Owerri, Nigeria[J]. Afr Health Sci, 2013, 13(2): 453-460.
[3] Laughlin SK, Schroeder JC, Baird DD. New directions in the epidemiology of uterine fibroids[J]. Semin Reprod Med, 2010, 28(3): 204-217.
[4] Saegusa M, Okayasu I. Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium[J]. Jpn J Cancer Res, 2000, 91(5): 510-518.
[5] Flierman PA, Oberyé JJ, van der Hulst VP, et al. Rapid reduction of leiomyoma volume during treatment with the GnRH antagonist ganirelix[J]. BJOG, 2005, 112(5): 638-642.
[6] Shao R, Fang L, Xing R, et al. Differential expression of estrogen receptor α and β isoforms in multiple and solitary leiomyomas[J]. Biochem Biophys Res Commun, 2015, 468(1-2): 136-142.
[7] Islam MS, Protic O, Giannubilo SR, et al. Uterine leiomyoma: available medical treatments and new possible therapeutic options[J]. J Clin Endocrinol Metab, 2013, 98(3): 921-934.
[8] Bulun SE, Moravek MB, Yin P, et al. Uterine leiomyoma stem cells: linking progesterone to growth[J]. Semin Reprod Med, 2015, 33(5): 357-365.
[9] Borahay MA, Al-Hendy A, Kilic GS, et al. Signaling pathways in leiomyoma: understanding pathobiology and implications for therapy[J]. Mol Med, 2015, 21(1): 242-256.
[10] 李亮, 宋成文, 杨赛花, 等. IGF-Ⅰ、IGF-Ⅱ、ER及PR在子宫组织的表达及肌瘤复发的意义[J]. 中国妇幼保健, 2015, 30(17): 2874-2876. LI Liang, SONG Chengwen, YANG Saihua, et al. Expressions and significance of IGF-Ⅰ, IGF-Ⅱ, ER, and PR in uterus[J]. Maternal & Child Health Care of China, 2015, 30(17): 2874-2876.
[11] Shaik NA, Lone WG, Khan IA, et al. Enhanced transcription of estrogen receptor α and mitochondrial cytochrome b genes in uterine leiomyomas[J]. Gynecol Endocrinol, 2011, 27(12): 1094-1098.
[12] Tsigkou A, Reis FM, Lee MH, et al. Increased progesterone receptor expression in uterine leiomyoma: correlation with age, number of leiomyomas, and clinical symptoms[J]. Fertil Steril, 2015, 104(1): 170-175.
[13] Kawaguchi K, Fujii S, Konishi I, et al. Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy[J]. Virchows Arch A Pathol Anat Histopathol, 1991, 419(4): 309-315.
[14] Moravek MB, Yin P, Ono M, et al. Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications[J]. Hum Reprod Update, 2015, 21(1): 1-12.
[15] Okumu LA, Forde N, Fahey AG, et al. The effect of elevated progesterone and pregnancy status on mRNA expression and localisation of progesterone and oestrogen receptors in the bovine uterus[J]. Reproduction, 2010, 140(1): 143-153.
[16] Godinjak Z, Bilalovic N. Estrogen and progesterone receptors in endometrium in women with unexplained infertility[J]. Mater Sociomed, 2014, 26(1): 51-52.
[17] Hammoud AO, Asaad R, Berman J, et al. Volume change of uterine myomas during pregnancy: do myomas really grow?[J]. J Minim Invasive Gynecol, 2006, l3(5): 386-390.
[18] Neiger R, Sonek JD, Croom CS, et al. Pregnancy-related changes in the size of uterine leiomyomas[J]. J Reprod Med, 2006, 51(9): 671-674.
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