JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (12): 69-72.doi: 10.6040/j.issn.1671-7554.0.2014.772

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Clinical characteristics and pregnancy outcomes of patients with systemic lupus erythematosus: a study of 66 cases with 67 pregnancies

WANG Likui, SANG Hongai, MA Yuyan, XU Yintao, WANG Linlin   

  1. Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-10-31 Revised:2014-11-11 Published:2014-12-10

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Abstract: Objective To investigate the clinical characteristics and pregnancy outcomes of patients with systemic lupus erythematosus (SLE). Methods Clinical datas of 66 pregnant women with 67 pregnancies (36 cases in flare group and 31 cases in non-flare group) with SLE treated in our hospital during Aug. 2005 and Aug. 2014 were collected and retrospectively analyzed. Results The incidence rates of preterm birth, small for gestational age infant, therapeutic abortion, pregnancy loss and severe preeclampsia increased significantly in the flare group compared with the non-flare group (all P<0.05). SLE was mostly active in the middle and late pregnancy, with the highest rate of proteinuria and skin rash, which were involved with multi-organ and multi-system damage, especially kidney damage. SLE flare in early pregnancy harmed the blood system, with or without skin rash. Conclusion SLE flare can lead to damage of the blood system, kidney and increased risks of poor fetal and maternal outcomes. Thus, for a better outcome of lupus pregnancy, it is essential to make a thoughtful plan, ensure a stable condition for at least 6 months before conception, and monitor the clinical indexes closely during pregnancy.

Key words: Pregnancy, Lupus Erythematosus, Systemic, Clinical characteristics, Pregnancy outcomes

CLC Number: 

  • R714.25
[1] Nikpour M, Bridge J A, Richter S. A systematic review of prevalence, disease characteristics, and management of systemic lupus erythematosus in Australia: Identifying areas of unmet need[J]. Intern Med J, 2014,Aug 28. doi: 10.1111/imj.12568.[Epub ahead of print].
[2] Doria A, Tincani A, Lockshin M. Challenges of lupus pregnancies[J]. Rheumatology (Oxford), 2008, 47 Suppl 3: i9-i12. doi: 10.1093/rheumatology/ken151.
[3] Al Arfaj A S, Khalil N. Pregnancy outcome in 396 pregnancies in patients with SLE in Saudi Arabia[J]. Lupus, 2010, 19(14): 1665-1673.
[4] D'Cruz D P, Khamashta M A, Hughes G R. Systemic lupus erythematosus[J]. Lancet, 2007, 369(9561):587-596.
[5] Stanhope T J, White W M, Moder K G, et al. Obstetric nephrology: lupus and lupus nephritis in pregnancy[J]. Clin J Am Soc Nephrol, 2012,7(12): 2089-2099.
[6] Ostensen M, Brucato A, Carp H, et al. Pregnancy and reproduction in autoimmune rheumatic diseases[J]. Rheumatology, 2011, 50(4): 657-664.
[7] 李吴萍, 王海英, 杨霞, 等. 影响系统性红斑狼疮活动指数评分的主要指标分析[J]. 中华风湿病学杂志, 2012, 16(5): 343-345. LI Wuping, WANG Haiying, YANG Xia, et al. The analysis of key indicators what may affect the activity index in systemic lupus erythematosus[J]. Chinese Journal of Rheumatology, 2012, 16(5): 343-345.
[8] 张岩, 杨慧霞, 廖秦平. 妊娠合并系统性红斑狼疮的妊娠结局及预后[J]. 中华围产医学杂志, 2012, 12(2): 117-122. ZHANG Yan, YANG Huixia, LIAO Qinping. Pregnant outcomes and prognosis of women complications with systemic lupus erythematosus[J]. Chinese Journal of Perinatal Medicine, 2012, 12(2): 117-122.
[9] Costenbader K H, Feskanich D, Stampfer M J, et al. Reproductive and menopausal factors and risk of systemic lupus erythematosus in women[J]. Arthritis Rheum, 2007, 56(4): 1251-1262.
[10] Clowse M E, Magder L S, Witter F, et al. The impact of increased lupus activity on obstetric outcomes[J]. Arthritis Rheum, 2005, 52(2): 514-521.
[11] Clowse M E, Magder L, Witter F, et al. Hydroxychloroquine in lupus pregnancy[J]. Arthritis Rheum, 2006, 54(11): 3640-3647.
[12] Yang H, Liu H, Xu D, et al. Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares-a case control study[J]. PLoS One, 2014, 9(8): e104375. doi:10.1371/journal.pone.0104375
[13] Madazli R, Yuksel M A, Oncul M, et al. Obstetric outcomes and prognostic factors of lupus pregnancies[J]. Arch Gynecol Obstet, 2014, 289(1):49-53.
[14] Morel N, Georgin-Lavialle S, Levesque K, et al. Neonatal lupus syndrome: Literature review[J]. Rev Med Interne, 2014. doi:10.1016/j.revmed.2014.07.013
[15] Lateef A, Petri M. Managing lupus patients during pregnancy[J]. Best Pract Res Clin Rheumatol, 2013, 27(3): 435-447.
[16] Zhao C, Zhao J, Huang Y, et al. New-onset systemic lupus erythematosus during pregnancy[J]. Clin Rheumatol, 2013, 32(6): 815-822.
[17] Kokeny G, Godo M, Nagy E, et al. Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice[J]. Lupus, 2007, 16(7): 465-477.
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