JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (2): 22-26.doi: 10.6040/j.issn.1671-7554.0.2014.732

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Curative effect of mechanical stress in the treatment of nonunion

LI Shangzhi, LIU Haichun, WU Wenliang, CAO Cong, CHEN Yunzhen   

  1. Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-10-22 Online:2015-02-10 Published:2015-02-10

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Abstract: Objective To observe the therapeutic effects of mechanical stress in treating nonunion in animal models. Methods Animal models of nonunion were built using self-adjustable external fixation. The models were then randomly divided into the experimental group and control group, with 30 animals in either group. The experimental group received axial pressure on the fracture end, while the control group received no pressure. Then nonunion was imaged and stained, and osteogenetic factors such as bone morphogenetic protein (BMP) and vascular endothelial growth factor (VEGF) were detected. Results There were statistical differences between the experimental group and control group (P<0.05). Calcium cobalt staining revealed that more osteoblasts were generated, and more amplification of BMP and VEGF were observed in the experimental group at different time points (both P<0.05). Conclusion Mechanical stress can promote the growth of osteoblasts and amplification of osteogenetic factors in the nonunion, and effectively accelerate its healing.

Key words: Mechanical stress, Rat model, Fracture, Nonunion, Osteogenetic factors

CLC Number: 

  • R687.1
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