JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2014, Vol. 52 ›› Issue (11): 106-112.doi: 10.6040/j.issn.1671-7554.0.2014.449

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Genetic polymorphisms of ADIPOQ and CAPN-10 and colorectal cancer risk

LIU Wenhui1, LI Xiaoling1, YUAN Ping1, LUAN Rongsheng1, FENG Fei1, HU Xiaoqin1, YAN Jin2, YANG Yanfang1   

  1. 1. Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan, China;
    2. Department of Intestinal Surgery, Sichuan Cancer Hospital, Chengdu 610041, Sichuan, China
  • Received:2014-07-08 Published:2014-11-10

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Abstract: Objective To explore the associations of ADIPOQ (rs2241766, rs1501299) and CAPN-10 (rs3842570, rs3792267) polymorphisms and gene-gene interaction with the risk of colorectal cancer(CRC). Methods A 1:1 matched case-control study was conducted to collect the demographic features, lifestyle, and dietary habits of 400 patients with newly histopathologically diagnosed CRC and 400 matched health controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the genotypes of ADIPOQ (rs2241766, rs1501299) and CAPN-10 (rs3842570, rs3792267). Conditional logistic regression was used to analyze the association of genetic polymorphisms of the 4 SNPs and CRC risk. Generalized multifactor dimensionality reduction (GMDR) was applied to test the gene-gene interaction on CRC risk. Results Compared with the wild genotypes, subjects carryingADIPOQ rs2241766 TG+GG genotype and CAPN-10 rs3792267 GA+AA genotype had the increased CRC risk (rs2241766: OR=1.354, 95%CI: 1.004-1.827; rs3792267: OR=1.507, 95%CI: 1.009-2.250), while those carrying ADIPOQ rs1501299 GT+TT genotype had an decreased CRC risk (OR=0.680, 95%CI:0.501-0.923). The association between CAPN-10 rs3842570 Del/Ins+Ins/Ins genotype and CRC risk was not significant (OR=1.345, 95%CI: 0.849-2.130). The GMDR showed that the gene-gene interaction among the 4 locus on CRC risk was significant (P=0.001). A significant dosage effect with an increasing number of risk genotypes was observed as the risk of CRC increased (χ2=13.302, P<0.001). Conclusion ADIPOQ rs2241766, ADIPOQ rs1501299, and CAPN-10 rs3792267 are associated with the risk of CRC, and the 4 locus might affect the risk of CRC together.

Key words: Genetic polymorphisms, Calpain 10 gene, Interactions, Colorectal cancer, Adiponectin gene

CLC Number: 

  • R735.3
[1] Parkin D M, Bray F, Ferlay J, et al.Global cancer statistics, 2002[J].CA Cancer J Clin, 2005, 55(2):74-108.
[2] 郑荣寿, 张思维, 吴良有, 等.中国肿瘤登记地区2008年恶性肿瘤发病和死亡分析[J].中国肿瘤, 2012, 21(1):1-12. ZHENG Rongshou, ZHANG Siwei, WU Liangyou, et al. Report of incidence and mortality from China cancer registries in 2008[J].China Cancer, 2012, 21(1):1-12.
[3] 骆秀婷, 许岸高.糖尿病与结直肠癌相关性的研究进展[J].医学综述, 2013, 19(9):1638-1640. LUO Xiuting, XU Angao.Research progress of relationship between diabetes and colorectal cancer[J].Medical Recapitulate, 2013, 19(9):1638-1640.
[4] Gulcelik M A, Colakoglu K, Dincer H, et al.Associations between adiponectin and two different cancers:breast and colon[J].Asian Pac J Cancer Prev, 2012, 13(1):395-398.
[5] Wei E K, Giovannucci E, Fuchs C S, et al.Low plasma adiponectin levels and risk of colorectal cancer in men:a prospective study[J].J Nati Cancer Inst, 2005, 97(22):1688-1694.
[6] An W, Bai Y, Deng S X, et al.Adiponectin levels in patients with colorectal cancer and adenoma:a meta-analysis[J].Eur J Cancer Prev, 2012, 21(2):126-133.
[7] 吴文君, 卜瑞芳, 沈泓, 等.2型糖尿病与代谢综合征患者血清脂联素水平及脂联素单核苷酸多态性45基因分析[J].临床荟萃, 2009, 24(12):1048-1051. WU Wenjun, BU Ruifang, SHEN Hong, et al. Serum adiponectin level and adiponectin gene SNP45 in patients with type 2 diabetes mellitus and metabolic syndrome[J].Clinical Focus, 2009, 24(12):1048-1051.
[8] AlSaleh A, O'Dell S D, Frost G S, et al.Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome[J].Am J Clin Nutr, 2011, 94(1):262-269.
[9] 路萍, 邵维斌, 夏春英, 等.CAPN-10基因与腹膜透析患者代谢综合征危险因素的关系[J].中国现代医学杂志, 2012, 22(2):55-64. LU Ping, SHAO Weibin, XIA Chunying, et al. Relationship between indel-19 polymorphisms of CAPN-10 gene and risk factors of MS in peritoneal dialysis patients[J].China Journal of Modern Medicine, 2012, 22(2):55-64.
[10] 邓梅香, 陈军建, 俞力, 等.钙蛋白酶10基因多态性与体重和胰岛素抵抗的相关性[J].现代预防医学, 2008, 35(22):4467-4474. DENG Meixiang, CHEN Junjian, YU Li, et al. Association of the CAPN10 gene with body mass index and insulin resistance[J]. Modern Preventive Medicine, 2008, 35(22):4467-4474.
[11] Shima Y, Nakanishi K, Odawara M, et al.Association of the SNP-19 genotype 22 in the calpain-10 gene with elevated body mass index and hemoglobin A1c levels in Japanese[J].Clin Chim Acta, 2003, 336(1-2):89-96.
[12] Horikawa Y, Oda N, Cox N J, et al.Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus[J].Nat Genet, 2000, 26(2):163-175.
[13] 李金娥,刘德敏,张喆.钙蛋白酶10基因多态性与2型糖尿病胰岛素抵抗的研究[J].天津医药,2008,36(2):96-98. LI Jin'e, LIU Demin, ZHANG Zhe.Study on the relationship between the gene polymorphism of CAPN10 and the resistance of type 2 diabetes mellitus[J].Tianjin Med J, 2008, 36(2):96-98.
[14] Li Y, Li X, Shi L, et al.Association of adiponectin SNP+45 and SNP+ 276 with type 2 diabetes in Han Chinese populations:a meta-analysis of 26 case-control studies[J].PLoS One, 2011, 6(5):e19686.
[15] Chung H K, Chae J S, Hyun Y J, et al.Influence of adiponectin gene polymorphisms on adiponectin level and insulin resistance index in response to dietary intervention in overweight-obese patients with impaired fasting glucose or newly diagnosed type 2 diabetes[J].Diabetes Care, 2009, 32(4):552-558.
[16] Hara K, Boutin P, Mori Y, et al.Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population[J].Diabetes, 2002, 51(2):536-540.
[17] Fong P Y, Fesinmeyer M D, White E, et al.Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokers[J].J Gastrointest Cancer, 2010, 41(3):203-208.
[18] Moreno-Luna R, Abrante A, Esteban F, et al.Calpain 10 gene and laryngeal cancer:a survival analysis[J].Head Neck, 2011, 33(1):72-76.
[19] Meyer T E, Boerwinkle E, Morrison A C, et al.Diabetes genes and prostate cancer in the atherosclerosis risk in communities study[J].Cancer Epidemiol Biomarkers Prev, 2010, 19(2):558-565.
[20] Johnson J D, Han Z, Otani K, et al.RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets[J]. J Biol Chem, 2004, 279(23):24794-24802.
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