JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Relationship between time and concentration of Lacto-tinidazole after drug combination

FANG Ying-li1, LIU Ai-ting2, ZHOU Wen1   

  1. 1. Department of Pharmacy, Qilu Hospital of Shandong University, Jinan 250012, China；2. Department of Pharmacy, West Ward of Shandong Provincial Hospital, Shandong University, Jinan 250022, China

  • Received:1900-01-01 Revised:1900-01-01 Online:2008-08-16 Published:2008-08-16
  • Contact: ZHOU Wen

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Abstract:

Objective〓〖WTBZ〗To offer a basis for rational clinical use of tinidazole and to guide breast feeding to neonates. 〖WTHZ〗Method〓〖WTBZ〗The Lacto-tinidazole concentrations at different times after intravenous drip tinidazole (800mg/d) were determined by HPLC using the self-control method. 〖WTHZ〗Results〓〖WTBZ〗Lacto-tinidazole concentration was statistically different among different patients and 0, 2, 4, 6, 8, 18 and 24h（P＜0.05）after the same patient received intravenous drip of tinidazole after two or three days. 〖WTHZ〗Conclusion〓〖WTBZ〗Tinidazole can be accumulated in patients after three days usage. So it should be cautiously used so as to reduce neonates passive absorption.

Key words: Tinidazole, Chromatography, high pressure liquid, Lactation, Infant, newborn

CLC Number: 

  • R978
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