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Interaction of triazole agents and Cyclosporin A against Candida albicans isolates in vitro

YU Jin-long 1，2， LI Yan3， GUO Qiong-jie1， SUN Shu-juan3   

  1. 1． Department of Pharmacology， School of Pharmaclutical Sciences， Shandong University， Jinan 250012， China；2． Department of Pharmaceutical Preparation， Second Hospital of Shandong University， Jinan 250033， China；3． Department of Pharmaceutical Preparation， Qianfoshan Hospital Affiliated to Shandong University， Jinan 250014， China

  • Received:1900-01-01 Revised:1900-01-01 Online:2008-08-16 Published:2008-08-16
  • Contact: SUN Shu-juan

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Abstract:

Objective〓〖WTBZ〗To explore the interaction of three azoles combined with Cyclosporin A against susceptive and resistant strains of C. albicans. 〖WTHZ〗Methods〓〖WTBZ〗The response was determined by the checkerboard micro-dilution method， and after the spectrophototric reading， the fractional inhibitory concentration index（FICI）was calculated. 〖WTHZ〗Results〓〖WTBZ〗Drugs combined together acted synergistically against resistant strains， while the interactions were mostly indifferent against susceptible strains. 〖WTHZ〗Conclusion〓〖WTBZ〗Cyclosporin A largely enhances the anti-fungal activity of azoles against resistant C.albicans strains but not against susceptive ones. The OD testing method is objective and convenient.

Key words: Triazoles, Cyclosporin A, Drug interactions, Antifungal agents, Candida albicans

CLC Number: 

  • R978.5
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