JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Correlation between TGF-β1 and hypertensive target organ damage

LIU Yu-ying1，WANG Li-qi2，ZHU Shi-ming2   

  1. 1.School of Medicine, Shandong University；2.Department of Cardiology, Jinan Central Hospital, Jinan 250013
  • Received:2007-01-08 Revised:1900-01-01 Online:2007-05-24 Published:2007-05-24
  • Contact: ZHU Shi-ming

PDF (PC)

564

Abstract: Objective： To investigate the relationship between the serum level of TGFβ1 and hypertensive target organ damage in patients with essential hypertension(EH). Methods： Eighty-two patients with EH were enrolled and divided into three groups based on the albumin-to-creatinine ratio (ACR): a group with ACR≥300mg/g (group A, n=28), a group with ACR＞30mg/g＜300mg/g (group B, n=31), and a group with ACR≤30mg/g (group C, n=23). Levels of ACR and AngⅡwere determined by radioimmunoassay, and serum TGFβ1 by a sandwich ELISA. The left ventricular telediastolic internal diameter, interventricular septum diastolic, posterior wall thickness, left ventricular mass index and left ventricular ejection fraction were determined by MB mode echocardiography. Results： TGFβ1 level was significantly higher in group A than in groups B and C(P＜0.01), and was also significantly different between group B and C(P＜0.05). TGFβ1 was directly related to ACR，AngⅡ and LVMI, but not related to BMI or blood pressure. Conclusion： TGFβ1, a useful marker plays an important role in the occurrence and progression of hypertensive target organ damage.

Key words: Essential hypertension, Transforming growth factor-beta, Angiotensin, Microalbuminuria, Left ventricular hypertrophy

CLC Number: 

  • R544.1
[1] WUYi-Na, GE Zhi-Ming, LI Fang, HE Hong, JIANG Hong, ZHANG Yun. Expressions of angiotensin converting enzyme 2 mRNA and protein in the kidneys in spontaneously hypertensive rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 5-.
[2] LI Rui, MA Weihong, REN Manyi, ZHAO Mengmeng, JIANG Shan, JU Yuanyuan, GUO Ying, SUN Zhaohui, SUI Shujian. Correlation between TWEAK and cardiac remodeling in essential hypertensive patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 49-55.
[3] GAO Jianbu, YANG Shouzhong, LI Yudong, QIAO Chong, ZHANG Songyu. Trend survey of inpatient use of drugs for acute myocardial infarction during 10 years in a hospital of Nanyang City [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 66-69.
[4] JIA Jiajing, WANG Zhiping. Effects of high exposure of endogenous reproductive hormones on perimenopausal and postmenopausal blood pressure in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(11): 7-14.
[5] WEI Dandan, ZHANG Cheng. Effects of the overexpression of type 4 angiotensin receptor on the formation of atherosclerotic lesions [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(8): 1-5.
[6] LIU Zhenzhong, JIANG Duyin, WANG Wei, ZONG Xianlei, ZHANG Jixun, LIU Lei. Proliferative effect of TGF-β1 phage model peptide on fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(3): 50-55.
[7] LIU Leilei, JU Yunfei, XU Wenfei, JU Yuanrong. Protective effect and possible mechanism of losartan on endotoxin-induced acute lung injury in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 6-11.
[8] HU Fangzhi, ZHANG Zhengjun, GENG Houfa, LIANG Qiuhua, SUN Lin. Relationship between microalbuminuria and brain damage in patients with type 2 diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 43-47.
[9] HAO Qingqing1,2,3, ZHANG Yonghuan1,2,3, YU Qingtao1,2, ZHU Li1,2, CHEN Xu1,2, LI Shuying1,2, WANG Laicheng1,2, ZHANG Yuehui1,4, LI Ruifeng3,. Effects of ACE2 gene transfection on adhesion molecules in atherosclerotic plaque of ApoE-/- mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(3): 1-6.
[10] MA Xiao1， WANG Yue-ming2， LI Hong-shi3, KAN Xiao-hong4，ZHAO Jing4, YUE Xin4, ZHANG Yun4, ZHONG Ming4, LI Li4. Evaluation of efficacy and safety of manidipine hydrochloride among patients with mild or moderate essential hypertension: a multicenter， randomized， doubleblind study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(8): 58-61.
[11] LIU Na, CAI Ke-li. Effect of Angiotensin (1-7) and Perindopril on expression of TGF-β1 in diabetic retina [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(5): 62-65.
[12] ZHAO Li-xiang， WU Xin-ning， WANG Xi， LI Na， CHEN Tong-shuai, LIU Jun-ni， BU Pei-li. Effects of NAD on the mRNA expression of collagen  type I induced by Angiotensin II in cardiac fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(3): 1-5.
[13] YANG Yan1, YAN Chun-ying1, CHEN Xu2, LIN Xiao-yan3, WANG Lai-cheng4, SHI Jun1. Effect of losartan on the rat model of experimental hepatic fibrosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(3): 27-31.
[14] QI Jia1, MA Yu-ru2, YANG Yong-li3, LI Li1, MA Xiao4. Analysis of linear and nonlinear heart rate variability in patients with essential hypertension and ventricular premature beats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(3): 68-71.
[15] LU Guan-yan1, CUI Bin2, LIU Zhong-liang3, LI Yu-tang4, LIU Xue-fei3, MA Xiao-jing1, ZHU Gui-yue1, YUAN Hai-tao1. Valsartan alters the balance of Th17 cells to regulatory T cells in chronic viral  myocarditis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(2): 1-.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd