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Effect of sesquiterpenoids on proliferation activity of prostate cancer cells

WANG Xiao-ling1，KONG Feng1，XU Ai-hui1，JI Kai2，CAI Jie1，REN Kai1，YUAN Hui-qing1   

  1. 1. Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan 250012, China； 2. Grade Five of Clinical Medicine (6 years), School of Medicine, Shandong University, Jinan 250012, China
  • Received:2007-09-07 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
  • Contact: YUAN Hui-qing

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Abstract: Objective To investigate the effects of sesquiterpenoids on proliferation of prostate cancer cells. MethodsThe growth of prostate cancer cells treated with sesquiterpenoids from myrrh was determined by MTT. The cell cycle was analyzed by flow cytometry. Also the expressions of p21WAF/CIP1(p21)（p21） and cyclinD at mRNA levels were determined by reverse transcription PCR (RT-PCR). ResultsThe two sesquiterpenoids significantly inhibited the proliferation of prostate cancer cells and caused a G0/G1 arrest, also it induced the expression of p21 and decreased the expression of cyclinD. ConclusionOverexpression of p21 and decrease of cyclinD might contribute to the two sesquiterpenoidmediated inhibitory effects on prostate cancer cell growth.

Key words: Myrrh, Sesquiterpenoid, Prostate cancer, Cell lines, p21, CyclinD

CLC Number: 

  • R963
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