JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (1): 52-57.doi: 10.6040/j.issn.1671-7554.0.2015.1042

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The expressions of PI3K/AKT and its related factors in colon cancer

ZHANG Xuequn1, GAO Wei2, PAN Pan3, GAO Junyi4   

  1. 1. Graduate School of Taishan Medical College, Taian 271016, Shandong, China;
    2. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. Department of Pathology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    4. Weifang Medical College, Weifang 261053, Shandong, China
  • Received:2015-10-30 Online:2016-01-11 Published:2016-01-11

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Abstract: Objective To investigate the expressions of PI3K/AKT signaling pathway and its related factors(PI3Kp110α, p-AKTser473, p-mTORser2448, CyclinD1)in colon cancer and their association with other clinical pathological parameters. Methods The expressions of PI3Kp110α, p-AKTser473, p-mTORser2448 and CyclinD1 were detected with immunohistochemical method in 65 cases of colon cancer(colon cancer group), and 15 cases of colonic adenoma(colonic adenoma group). The association between the expressions and clinical pathological parameters were analyzed. Results The positive expressions of PI3Kp110α, p-AKTser473, p-mTORser2448 and CyclinD1 were significantly higher in colon cancer than in colonic adenoma(all P<0.05). In the colon cancer group, there were no differences in the expressions of PI3Kp110α, p-AKTser473 and p-mTORser2448 between different genders, ages, different degrees of differentiation, lymph node metastasis and TNM staging(all P>0.05); while there were differences in the expression of CyclinD1 between varying degrees of differentiation and TNM staging(all P<0.05), but no statistical differences between different genders, ages and different degrees of lymph node metastasis(all P>0.05). In the 山 东 大 学 学 报 (医 学 版)54卷1期 -张雪群,等.PI3K/AKT及其相关因子在结肠癌中的表达 \=-colonic adenoma, there were no differences in the expressions of PI3Kp110α, p-AKTser473、 p-mTORser2448 and CyclinD1 between different genders, ages, degrees of differentiation, lymph node metastasis and TNM staging(all P>0.05). Conclusion The expressions of PI3Kp110α, p-AKTser473, p-mTORser2448 and CyclinD1 are closely related with the occurrence and development of colon cancer, playing a significant role in the prognosis of colon cancer and new research targets.

Key words: p-AKTser473, p-mTORser2448, Colon cancer, PI3Kp110α, CyclinD1

CLC Number: 

  • R735.3
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