JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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A comparison of a rat hind-limb ischemia model established by ligation and embolization

LIANG Cui-hong1，TIAN Hua2，XU Yun2，LI Gui-bao2，TIAN Guang-ping2, SONG Tao2   

  1. 1. Department of Anatomy, Weifang Medical College, Weifang, Shandong, China; 2. Department of Anatomy, School of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2006-12-29 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
  • Contact: TIAN Hua

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Abstract: Objective: To explore an effective method for establishing a hindlimb ischemia model in rats. Methods: Wistar rat hindlimb ischemia models were established by three methods: ligation of the femoral artery, ligation of the common iliac artery, embolization of the femoral artery with fine particles of common bletilla tuber (FPCBT). From 1 to 21 days after operation, the ischemia and function had been observed. Results: ① Temporal limp happened in the operated hindlimbs after ligating the femoral artery or the common iliac artery, and no pathological changes were found in the tissue sections; ② At 3 to 21 days after embolizing the femoral artery by FP-CBT, severe ischemia occurred in the operated hindlimbs, such as sustained limping, skin necrosis or ulcers, and muscle fibers necrosis which was recognized by HE staining. Conclusion: Hindlimb ischemia can not be produced by ligating the artery. However, it can be well induced by embolizing the femoral artery with FP-CBT.

Key words: Ischemia model, Ligation, Common bletilla tuber, Embolization, Hindlimb, Rat

CLC Number: 

  • R332
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