JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Expression of PDGF and its receptor on pancreas fibrosis in rats

WANG Dongsheng1, LIU Qian2, KOU Yan3   

  1. 1. School of Medicine, Shandong University, Jinan 250012; 2.Department of Digestion,Shandong Provincial Qianfoshan Hospital, Jinan 250014; 3. Department of Burn, Jinan Fourth People′s Hospital, Jinan 250031
  • Received:2005-08-12 Revised:1900-01-01 Online:2006-04-24 Published:2006-04-24

Abstract: Objective: To study the expression and significance of PDGF and its receptor in the process of pancreas fibrosis. Methods: The animal model of chronic pancreatitis was established by injection of 2% TNBS to rat′s pancreatic duct. Expressions of PDGF, PDGFR and αSMA were determined in pancreas tissues in different stages by using immnnohistochemistry technique. Results: Expressions of PDGFB, PDGFRβ and αSMA were stronger in model than in control group on the fourth week. There was a positive correlation between αSMA and PDGFB and PDGFRβ, and no correlation between αSMA and PDGFA and PDGFRα. The expressions of PDGFB and PDGFRβ were stronger than those of PDGFA and PDGFRα with a significant difference in model group. Conclusion: PDGFB and PDGFRβ are mainly to act play a key role in pancreas fibrosis and development.

Key words: Receptors, plateletderived growth factor, Pancreatitis, Rat, Wistar

CLC Number: 

  • R576
[1] WUYi-Na, GE Zhi-Ming, LI Fang, HE Hong, JIANG Hong, ZHANG Yun. Expressions of angiotensin converting enzyme 2 mRNA and protein in the kidneys in spontaneously hypertensive rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 5-.
[2] ZHU Lin, HU San-Yuan, ZHANG Guang-Yong, DING Xiang-Jiu. Protection of PGE2 against intestinal mucosa injuries in obstructed jaundice rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 12-.
[3] SUN Tao, ZHANG Dao-Lai, XIE Shan-Shan, WANG Yu-Zhuo, FENG Yu-Xin, XIN Hua. Effect of ethanol on expression of connexin 43 in primary culture of neural precursor cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 20-.
[4] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[5] WANG Xiao-Lei, ZHANG Hai-Thao, ZHANG Hui, GUO Cheng-Hao. Protective effects of shuxuening injecta on vascular  endothelial  cell injury in vitro due to iodine excesses [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 38-.
[6] LU Xiang-Dong, YANG Wei, XU Guang-Meng, QU Yuan-Ming. Expression and role of PPAR-γin meningiomas and troglitazone induced meningiomas cell apoptosis in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 65-.
[7] ZHANG Xiao-Yan, LI Gang, WANG Ling-Beng. Effects of different dosages of Sufentanil in induced general anesthesia  period on blood rheology cortisol in spinal operations [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 76-79.
[8] WANG Xin, XING Chun-Yan, YANG Yan-Ping. Serum phosphopyruvate hydratase in diagnosis of invasive Candida albicans infection [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 92-94.
[9] YU De-Xin, CAEI Ti-Gong, MA Xiang-Xing, ZHANG Xiao-Ming, LI Chuan-Fu. Angiogenesis and maturation of hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 51-54.
[10] LI Han, FU Tingting, ZHANG Lei, YAN Bing, SUN Tao, GUO Feng, YIN Xiao. Effects of PPARγ agonist rosiglitazone on the differentiation of beige adipocytes in 24 obese individuals [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 8-13.
[11] ZHANG Hongbin, ZHAO Hanhui, WANG Suxia, ZHOU Peng, HE Qingqing, WANG Yanqun, DING Weiping, LIU Gang. Perioperative observation and postoperative risk factors of severe hypocalcemia after parathyroidectomy: a report of 303 cases [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 14-20.
[12] SUN Yifeng, GAO Yu, LIANG Yongyuan, GAO Yang. Expression of CPLX2 and its in vitro effects on the proliferation migration and invasion of hepatocellular carcinoma cells [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 34-39.
[13] GAO Pei, MAO Changlin, CHEN Feng, HE Wei, GUAN Yong,LYU Jiaju, LI Shanjun, DING Sentai. Application of CT three-dimensional reconstruction modified R.E.N.A.L. score in 50 cases of laparoscopic partial nephrectomy [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 52-57.
[14] FAN Jiayin, ZHAO Di, GUO Lei, JIA Liying. Health financing fairness of households in three regions of Shandong Province [J]. Journal of Shandong University (Health Sciences), 2020, 1(9): 89-94.
[15] Chuanzhu YAN,Wei WANG,Kunqian JI,Yuying ZHAO. Mitochondrial dysfunction and related brain diseases [J]. Journal of Shandong University (Health Sciences), 2020, 1(8): 34-41.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd