JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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An experimental study on repairing of facial nerve defects with

  

  1. 1. Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital, Shandong Uiversity, Jinan 250021,
  • Received:2006-02-10 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24

Abstract: To evaluate the effect of complex chitosan conduits containing Schwann cells(SCs) in repairing of facial nerve defects. Methods: Complex chitosan conduits were made from chitosan and carboxymethylchitosan by freeze drying method in proportion of 3 to 1. Schwann cells were obtained from sciatic nerves of new born rabbits, and then were cultured and numberenlarged. After being combined with SCs, the complex chitosan conduits were used to repair a 0.8?cmdefect of facial nerve. The nerve regeneration was evaluated by gross, electrophysiological andstological examinations after 4, 8 and 16 weeks, and were compared with the results of using conduits only. Results: New nerve had bridged the defects 8 weeks after operation, and most of the conduits had degraded 16 weeks after operation. Compared with chitosan conduits only , the conduits+ SCs group had better electrophysiological and histological results. Conclusion: The complex chitosan conduit combined with SCs is a better method for repairing of facial nerve defects.

Key words: Chitosan, Schwann cells, Nerve repair, Facial nerve, Rabbits

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