Journal of Shandong University (Health Sciences) ›› 2024, Vol. 62 ›› Issue (2): 1-9.doi: 10.6040/j.issn.1671-7554.0.2024.0045

• Expert Overview •    

Role of cholesterol metabolism in osteoarthritis: a review of research progresses

ZHAO Zhibo1,2, MAN Zhentao2, LI Wei1,2   

  1. 1. Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2024-03-29

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Abstract: Osteoarthritis(OA)is a degenerative disease associated with aging and has long been linked to obesity. Some studies suggest that OA might be a metabolic disease, impacting not only weight-bearing joints but also non-weight-bearing joints. Emerging evidence indicates abnormal cholesterol metabolism in osteoarthritis, with pathways leading to the production of pro-inflammatory substances crucial to OA development. Drugs capable of modulating abnormal cholesterol metabolism hold considerable therapeutic promise for OA. This article aims to summarize the role and comprehensive molecular mechanisms of cholesterol metabolism in osteoarthritis and proposes that a multi-faceted regulation of cholesterol metabolism could be a promising strategy for the clinical treatment of osteoarthritis.

Key words: Osteoarthritis, Metabolic syndrome(MetS), Cholesterol metabolism disorder, Oxidized low density lipoprotein, Cholesterol metabolism

CLC Number: 

  • R687.4+1
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