JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2015, Vol. 53 ›› Issue (6): 94-96.doi: 10.6040/j.issn.1671-7554.0.2014.454

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Significance of type Ⅱ collagen biomarker C2C in the diagnosis of knee osteoarthritis

XIN Linwei, WANG Liming, LI Chaoxu, TANG Jicun, JIANG Mengyao, QU Quanli   

  1. Department of Orthopaedics, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi, China
  • Received:2014-07-10 Revised:2015-02-28 Published:2015-06-10

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Abstract: Objective To discuss the association between the level of type Ⅱ collagen biomarker C2C in urine and severity of knee osteoarthritis (KOA). Methods Urine samples and anteroposterior and lateral films of knee joint of 90 KOA patients (KOA group) and 20 healthy controls (control group) were collected and compared. According to Kellgren-Lawrence radiographic grading criteria, patients in the KOA group were divided into grade Ⅰ, Ⅱ, Ⅲ, and Ⅳ subgroups. Urine C2C level was detected with enzyme-linked immunosorbent assay (ELISA). Results Urine C2C level in KOA group was significantly higher than that in control group (P<0.01). In the subgroups, the C2C level in subgroup Ⅳ was the highest, followed by subgroup Ⅲ, Ⅱ and Ⅰ (P=0.000). The C2C level in subgroup I was similar to that in control group, with no significant difference (P>0.05). Conclusion The urine C2C level may serve as an indicator for the progression and curative effect of KOA, rather than an index for the early diagnosis of KOA.

Key words: C2C, Urine, Cartilage metabolites, Knee osteoarthritis, Type Ⅱcollagen

CLC Number: 

  • R684.3
[1] Ishijima M, Watari T, Naito K, et al. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis[J]. Arthritis Res Ther, 2011, 13(1): 22.
[2] Hayashi K, Kim SY, Lansdowne JL, et al. Evaluation of a collagenase generated osteoarthritis biomarker in naturally occurring canine cruciate disease[J]. Veterinary Surgery, 2009, 38(1): 117-121.
[3] Martín-Millán M, Castañeda S. Estrogens, Osteoarthritis and inflammation[J]. Joint Bone Spine, 2013, 80(4): 368-373.
[4] Christgau S, Garnero P, Fledelius C, et al. Collagen type Ⅱ C-telopeptide fragments as an index of cartilage degradation[J]. Bone, 2001, 29(3): 209-215.
[5] Eyre DR, Oguchi H. The hydroxypyridinium crosslinks of skeletal collagens: their measurement, properties and a proposed pathway of formation[J]. Biochem Biophys Res Commun, 1980, 92(2): 403-410.
[6] Cibere J, Zhang H, Garnero P, et al. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study[J]. Arthritis Rheum, 2009, 60(5): 1372-1380.
[7] Van Spil WE, DeGroot J, Lems WF, et al. Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria[J]. Osteoarthritis Cartilage, 2010, 18(5):605-612.
[8] Ishijima M, Kaneko H, Kaneko K, et al. The evolving role of biomarkers for osteoarthritis[J]. Ther Adv Musculoskelet Dis, 2014, 6(4): 144-153.
[9] Attur M, Krasnokutsky-Samuels S, Samuels J, et al. Prognostic biomarkers in osteoarthritis[J]. Curr Opin Rheumatol, 2013, 25(1): 136-144.
[10] Hunter DJ, Nevitt M, Losina E, et al. Biomarkers for osteoarthritis: current position and steps towards further validation[J]. Best Pract Res Clin Rheumatol, 2014, 28(1):61-71.
[11] Cahue S, Sharma L, Dunlop D, et al. The ratio of type Ⅱ collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis[J]. Osteoarthritis Cartilage, 2007, 15(7): 819-823.
[12] He G, Chen X, Zhang G, et al. Detection of urine C2C and trace element level in patients with knee osteoarthritis[J]. Cell Biochem Biophys, 2014, 70(1): 475-479.
[13] Conrozier T, Poole AR, Ferrand F, et al. Serum concentrations of type Ⅱ collagen biomarkers (C2C, C1, 2C and CPII) suggest different pathophysiologies in patients with hip osteoarthritis[J]. Clin Exp Rheumatol, 2008, 26(3): 430-450.
[14] Bakker MF, Verstappen SM, Welsing PM, et al. The relation between cartilage biomarkers (C2C, C1,2C, CS846, and CPII) and the long-term outcome of rheumatoid arthritis patients within the CAMERA trial[J]. Arthritis Research & Therapy, 2011, 13(3): 70.
[15] Jordan CD, McWalter EJ, Monu UD, et al. Variability of cubequant T1ρ, quantitative DESS T2, and cones sodium MRI in knee cartilage[J]. Osteoarthritis Cartilage, 2014, 22(10): 1559-1567.
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