Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (9): 79-83.doi: 10.6040/j.issn.1671-7554.0.2023.0400

• Clinical Medicine • Previous Articles     Next Articles

Efficacy of Fuyueshu plant drink in the treatment of primary dysmenorrhea

ZHAO Tong1, SU Xing1, WANG Kai1,2   

  1. 1. Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    2. Institute of Hepatology, Shandong University, Jinan 250012, Shandong, China
  • Received:2023-05-11 Published:2023-10-10

PDF (PC)

64

Abstract: Objective To explore the effects of Fuyueshu plant drink on primary dysmenorrhea. Methods A total of 32 patients with dysmenorrhea treated during Aug. 26 and Oct. 3, 2022 were included. The patients received ibuprofen sustained-release capsules in the first menstrual cycle and Fuyueshu in the second menstrual cycle. The pain, breast pain, chest and hypochondriac pain, chills, cold sweat, nausea, vomiting, diarrhea, dizziness, fatigue, irritability and serological indicators were compared between the two cycles. Results The total response rate of Fuyueshu was higher than that of ibuprofen(81.25% vs 43.75%). Fuyueshu was significantly better than ibuprofen in improving chills, cold sweat, diarrhea, dizziness, headache, fatigue and irritability(P<0.05). The two had comparable effects on the improvement of breast pain, nausea and vomiting, serum prostaglandin E2(PGE2), prostaglandin 2α(PGF2α)and β-endorphin(β-EP). Fuyueshu was superior to ibuprofen in increasing the level of tumor necrosis factor-α(TNF-α)(P<0.001). Conclusion Fuyueshu can effectively improve the clinical symptoms and serological indexes of primary dysmenorrhea.

Key words: Primary dysmenorrhea, Fuyueshu plant drink, Ibuprofen sustained-release capsule, Clinical symptoms, Tumor necrosis factor-α

CLC Number: 

  • R711
[1] Hu Z, Tang L, Chen L, et al. Prevalence and risk factors associated with primary dysmenorrhea among Chinese female university students: a cross-sectional study [J]. J Pediatr Adolesc Gynecol, 2020, 33(1): 15-22.
[2] Marjoribanks J, Ayeleke RO, Farquhar C, et al. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea [J]. Cochrane Database Syst Rev, 2015, 2015(7): CD001751. doi: 10.1002/14651858.CD001751.pub3.
[3] 聂文佳, 徐帅师, 张咏梅. 原发性痛经治疗方法的研究进展[J]. 中国中医基础医学杂志, 2021, 27(4): 683-689. NIE Wenjia, XU Shuaishi, ZHANG Yongmei. Research progress in treatment of primary dysmenorrhea [J]. Journal of Basic Chinese Medicine, 2021, 27(4): 683-689.
[4] 许栋涵, 罗业浩, 方刚, 等. 痛经病因病机古文献研究进展 [J]. 辽宁中医药大学学报, 2023, 25(4): 77-80. XU Donghan, LUO Yehao, FANG Gang, et al. A summary of the progress in understanding the etiology and pathogenesis of dysmenorrhea in ancient literature [J]. Journal of Liaoning University of TCM, 2023, 25(4): 77-80.
[5] Wang Y, Yang L, Zhang X, et al. Quality marker discovery of Danggui Jianzhong decoction for treating primary dysmenorrhoea based on chinmedomics strategy [J]. Phytomedicine, 2023, 115: 154724. doi: 10.1016/j.phymed.2023.154724.
[6] 蒲宝婵, 姜国云, 方玲. 原发性痛经疼痛因子及其关联性研究[J]. 中华中医药学刊, 2014, 32(6): 1368-1370. PU Baochan, JIANG Guoyun, FANG Ling. Research on pain related factors and associations of primary dysmenorrhea [J]. Chinese Archives of Traditional Chinese Medicine, 2014, 32(6): 1368-1370.
[7] 李英, 孙兴云. 布洛芬缓释胶囊联合经痛康颗粒对原发性痛经患者炎症因子、β-EP、PGE2及PGF2a的影响[J]. 中国妇幼保健, 2015, 30(17): 2854-2856.
[8] 孙菲菲, 何佳. 温针灸结合艾灸神阙穴治疗寒凝血瘀型原发性痛经的效果及对痛经症状、前列腺素、β-EP水平的影响[J]. 临床医学研究与实践, 2022, 7(14): 126-129. SUN Feifei, HE Jia. Effect of warm acupuncture combined with moxibustion at Shenque point on primary dysmenorrhea of cold coagulation and blood stasis type and its influences on dysmenorrhea symptoms, prostaglandin and β-EP levels [J]. Clinical Research and Practice, 2022, 7(14): 126-129.
[9] Huang WC, Chiu PC, Ho CH. The sprint-interval exercise using a spinning bike improves physical fitness and ameliorates primary dysmenorrhea symptoms through hormone and inflammation modulations: a randomized controlled trial [J]. J Sports Sci Med, 2022, 21(4): 595-607.
[10] 刘敏, 温权, 唐远军, 等. 董氏奇穴联合艾灸对原发性痛经患者β-内啡肽和机械性痛阈水平的影响[J]. 河北中医, 2023, 45(2): 283-286. LIU Min, WEN Quan, TANG Yuanjun, et al. Effect of Dongs Qi point combined with moxibustion on β-endorphin and mechanical threshold in patients with primary dysmenorrhea [J]. Hebei Journal of Traditional Chinese Medicine, 2023, 45(2): 283-286.
[11] Barcikowska Z, Grzybowska ME, Wz P, et al. Effect of manual therapy compared to ibuprofen on primary dysmenorrhea in young women-concentration assessment of c-Reactive protein, vascular endothelial growth factor, prostaglandins and xex hormones [J]. J Clin Med, 2022, 11(10): 2686. doi: 10.3390/jcm11102686.
[12] Ma B, Yang S, Tan T, et al. An integrated study of metabolomics and transcriptomics to reveal the anti-primary dysmenorrhea mechanism of Akebiae Fructus [J]. J Ethnopharmacol, 2021, 270: 113763. doi: 10.1016/j.jep.2020.113763.
[13] 陈金芳, 雷静, 林能兴. 带状疱疹患者血清PGE2、IL-6、TNF-α水平及病毒载量与病情严重程度的相关性[J]. 中国微生态学杂志, 2021, 33(2): 201-204. CHEN Jinfang, LEI Jing, LIN Nengxing. Correlation between prostaglandin E2, interleukin 6, tumor necrosis factor-α, varicella-zoster virus load and severity of disease in patients with herpes zoster [J]. Chinese Journal of Microecology, 2021, 33(2): 201-204.
[14] 付华君, 常建华, 朱利娟, 等. 纳布啡复合右美托咪定对腹腔镜胃肠肿瘤根治术病人血清β-内啡肽、前列腺素-E2、肿瘤坏死因子-α及白细胞介素-6水平影响 [J]. 临床外科杂志, 2022, 30(6): 545-547. FU Huajun, CHANG Jianhua, ZHU Lijuan, et al. Effects of naborphine combined with dexmedetomidine on the serum β-EP, PGE2, TNF-α and IL-6 in patients with undergoing laparoscopic radical gastrectomy [J]. Journal of Clinical Surgery, 2022, 30(6): 545-547.
[15] Peng Y, Zheng X, Fan Z, et al. Paeonol alleviates primary dysmenorrhea in mice via activating CB2R in the uterus [J]. Phytomedicine, 2020, 68: 153151. doi: 10.1016/j.phymed.2019.153151.
[16] 郑仁省, 刘金里. 芍药甘草汤对痛经患者血清IL-1β、TNF-α及疼痛的影响 [J]. 长春中医药大学学报, 2017, 33(4): 614-616. ZHENG Rensheng, LIU Jinli. Effect of ffect of Shaoyao Gancao haoyao Gancaodecoction on serum IL-1 decoction on serum IL-1β, TNF-αand pain of patients with and pain of patients with dysmenorrheal [J]. Journal of Changchun University of Chinese Medicine, 2017, 33(4): 614-616.
[17] 黄意娟, 傅文君, 王宝娣. 黄葵胶囊治疗原发性痛经的临床疗效及对血清白细胞介素-10、肿瘤坏死因子-α及γ-干扰素水平的影响[J]. 中国妇幼保健, 2017, 32(11): 2358-2360.
[18] 朱秀英, 李永平, 孙小月, 等. 五禽戏联合推拿对原发性痛经患者中医证候及血清TNF-α、CD4+、OT、β-EP表达的影响 [J]. 新中医, 2021, 53(2): 201-205. ZHU Xiuying, LI Yongping, SUN Xiaoyue, et al. Effect of five mimic-animal exercise combined with tuina on Chinese medicine syndromes and expressions of TNF-α,CD4+, OT and β-EP in serum in patients with primary dysmenorrhea[J]. Journal of New Chinese Medicine, 2021, 53(2): 201-205.
[1] ZENG Rong, WU Jinxiang, ZHANG Jintao, SHANGGUAN Hong, ZHOU Shengyu, TIAN Tian, DONG Liang. Primary pulmonary angiosarcoma: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2021, 59(2): 19-25.
[2] ZHAO Qingqing, YIN Geping. Association between genetic polymorphisms of 5 genetic loci of TNF-α promoter and genetic susceptibility to cervical cancer [J]. Journal of Shandong University (Health Sciences), 2018, 56(2): 28-33.
[3] LIAN Kaili, LI Yan, ZHANG Na, JIN Guiyuan, LIU Suxia. TIPE3 decreases breast cancer cell sensitivity to adriamycin by upregulating P-gp protein expression [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(5): 36-42.
[4] YU Yujuan, GAO Chengjie, WANG Xiaopeng, LI Bo. Effects of parecoxibsodium on inflammatory response and its neuroprotection in patients undergoing brain tumor surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 65-68.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] MA Qingyuan, PU Peidong, HAN Fei, WANG Chao, ZHU Zhoujun, WANG Weishan, SHI Chenhui. Effect of miR-27b-3p regulating SMAD1 on osteosarcoma cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 32 -37 .
[2] SUO Dongyang, SHEN Fei, GUO Hao, LIU Lichang, YANG Huimin, YANG Xiangdong. Expression and mechanism of Tim-3 in animal model of drug-induced acute kidney injury[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 1 -6 .
[3] ZHANG Baowen, LEI Xiangli, LI Jinna, LUO Xiangjun, ZOU Rong. miR-21-5p targeted TIMP3 to inhibit proliferation and extracellular matrix accumulation of mesangial cells in Type II diabetic nephropathy mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 7 -14 .
[4] FU Jieqi, ZHANG Man, ZHANG Xiaolu, LI Hui, CHEN Hong. Molecular mechanism of Toll-like receptor 4 in the aggravation of blood lipid accumulation by inhibiting the peroxisome proliferator-activate receptor γ[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 24 -31 .
[5] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15 -23 .
[6] LI Ning, LI Juan, XIE Yan, LI Peilong, WANG Yunshan, DU Lutao, WANG Chuanxin. Expression of LncRNA AL109955.1 in 80 cases of colorectal cancer and its effect on cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 38 -46 .
[7] DING Xiangyun, YU Qingmei, ZHANG Wenfang, ZHUANG Yuan, HAO Jing. Correlation of the expression of insulin-like growth factor II in granulosa cells and ovulation induction outcomes of 84 patients with polycystic ovary syndrome[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 60 -66 .
[8] XU Yuxiang, LIU Yudong, ZHANG Peng, DUAN Ruisheng. A retrospective analysis of risk factors of cerebral microbleeds in 101 patients with cerebral small vessel disease[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 67 -71 .
[9] XIAO Juan, XIAO Qiang, CONG Wei, LI Ting, DING Shouluan, ZHANG Yuan, SHAO Chunchun, WU Mei, LIU Jianing, JIA Hongying. Comparison of diagnostic efficacy of two kinds of thyroid imagine reporting and data systems[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 53 -59 .
[10] SHI Shuang, LI Juan, MI Qi, WANG Yunshan, DU Lutao, WANG Chuanxin. Construction and application of a miRNAs prognostic risk assessment model of gastric cancer[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 47 -52 .
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd