Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (11): 53-60.doi: 10.6040/j.issn.1671-7554.0.2022.0302

• Clinical Medicine • Previous Articles    

Effect of ear acupoint electroacupuncture combined with high-frequency repetitive transcranial magnetic stimulation on post-stroke depression

WANG Litong1,2, WANG Zhan2, WU Jingyi2, WU Yanying2, LI Yongna3, TANG Hong1   

  1. 1. School of Biomedical Engineering, School of Medicine, Dalian University of Technology, Dalian 116024, Liaoning, China;
    2. Rehabilitation Department of the Second Affiliated Hospital of Dalian Medical University, Dalian 116031, Liaoning, China;
    3. Rehabilitation Department of Dalian Pulandian Geriatric Hospital, Dalian 116020, Liaoning, China
  • Published:2025-11-28

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Abstract: Objective To observe the efficacy of ear-point electroacupuncture combined with high-frequency repetitive transcranial magnetic stimulation(rTMS)on patients with post-stroke depression, thereby providing a new clinical treatment regimen. Methods A total of 140 patients with post-stroke depression, who attended the Second Affiliated Hospital of Dalian Medical University from February 2023 to December 2024, were randomly divided into a control group and three experimental groups(ear-point electroacupuncture group, rTMS group, and ear-point combined with rTMS group). The patients scores on the Hamilton Depression Scale-17(HAMD-17), Self-Rating Depression Scale(SDS), Montreal Cognitive Assessment(MoCA), Modified Barthel Index(MBI), and Clinical Neurological Deficit Scale(CNDS), as well as the levels of 5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)were compared. Results After treatment, significant reductions were observed in HAMD-17, SDS, and CNDS scores(P<0.05), with significant increases in MoCA and MBI scores(P<0.05), and elevated levels of 5-HT and BDNF(P<0.05), in all groups compared to pre-treatment. The ear-point combined with rTMS group, ear-point electroacupuncture group, and rTMS group showed more significant reductions in HAMD-17, SDS, and CNDS scores, and increases in MBI scores and 5-HT and BDNF levels, compared to the control group(P<0.05). The ear-point combined with rTMS group demonstrated superior outcomes in these measures compared to the other two experimental groups(P<0.05). Conclusion Ear-point electroacupuncture combined with high-frequency rTMS significantly improves various indicators in patients with PSD.

Key words: Stroke, Depression, Ear acupoint electroacupuncture, Repetitive transcranial magnetic stimulation

CLC Number: 

  • R741
[1] Villa RF, Ferrari F, Moretti A. Post-stroke depression: mechanisms and pharmacological treatment[J]. Pharmacol Ther, 2018, 184: 131-144. doi:10.1016/j.pharmthera.2017.11.005
[2] Schöttke H, Gerke L, Düsing R, et al. Post-stroke depression and functional impairments—a 3-year prospective study[J]. Compr Psychiatry, 2020, 99: 152171. doi:10.1016/j.comppsych.2020.152171
[3] Guo JL, Wang JJ, Sun W, et al. The advances of post-stroke depression: 2021 update[J]. J Neurol, 2022, 269(3): 1236-1249.
[4] Volz M, Ladwig S, Werheid K. Gender differences in post-stroke depression: a longitudinal analysis of prevalence, persistence and predictive value of known risk factors[J]. Neuropsychol Rehabil, 2021, 31(1): 1-17.
[5] 黄朝云, 陈斌. 脑卒中后抑郁的研究进展[J]. 医学新知杂志, 2012, 22(6): 401-404.
[6] 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国各类主要脑血管病诊断要点2019[J]. 中华神经科杂志, 2019, 52(9): 710-715.
[7] 中华医学会精神病学分会. 中国精神障碍分类与诊断标准第三版(精神障碍分类)[J]. 中华精神科杂志, 2001, 34(3): 184-188.
[8] 国家质量监督检验检疫总局 中国国家标准化管理委员会. 耳穴名称与定位: GB/T 13734—2008[S]. 北京: 中国标准出版社, 2008.
[9] 赵璇, 李晓鹏, 李剑, 等. 磁珠耳穴贴压联合重复经颅磁刺激对脑卒中后抑郁的疗效[J]. 山东大学学报(医学版), 2022, 60(1): 65-70. ZHAO Xuan, LI Xiaopeng, LI Jian, et al. Therapeutic effects of auricular points sticking with magnetic beads combined with repeated transcranial magnetic stimulation on post-stroke depression[J]. Journal of Shandong University(Health Science), 2022, 60(1): 65-70.
[10] 邓良彬, 石一杰. 耳穴压豆联合盐酸氟西汀治疗卒中后抑郁的临床观察[J]. 中国民间疗法, 2022, 30(14): 80-82. DENG Liangbin, SHI Yijie. Clinical observation of auricular acupoint pressing bean combined with fluoxetine hydrochloride in treating post-stroke depression[J]. Chinas Naturopathy, 2022, 30(14): 80-82.
[11] 白丽敏. 柴胡疏肝散联合耳针治疗脑卒中后抑郁肝郁气滞型疗效观察[J]. 实用中医药杂志, 2024, 40(11): 2134-2136.
[12] 王日旺, 彭嘉慧, 张志远, 等. 重复经颅磁刺激改善脑卒中所致肢体功能障碍的临床研究现状[J]. 大连医科大学学报, 2021, 43(2): 149-154. WANG Riwang, PENG Jiahui, ZHANG Zhiyuan, et al. Research progress on the improvement of stroke-relatedlimb dysfunction by repetitive transcranial magnetic stimulation[J]. Journal of Dalian Medical University, 2021, 43(2): 149-154.
[13] Herrington JD, Heller W, Mohanty A, et al. Localization of asymmetric brain function in emotion and depression[J]. Psychophysiology, 2010, 47(3): 442-454.
[14] 李志平, 李建军, 张志明. 艾地苯醌片联合经颅磁刺激治疗缺血性脑卒中后抑郁的临床效果[J]. 临床合理用药, 2025, 18(2): 1-3. LI Zhiping, LI Jianjun, ZHANG Zhiming. Clinical effect of idebenone tablets combined with transcranial magnetic stimulation in the treatment of depression after ischemic stroke[J]. Chinese Journal of Clinical Rational Drug Use, 2025, 18(2): 1-3.
[15] 褚睿, 宋雅婷, 周胜男, 等. 疏脑解郁汤联合调督解郁灸法-经颅磁刺激(rTMS)对卒中后抑郁患者康复治疗中的疗效观察[J/OL]. 中华中医药学刊, 2025: 1-11.(2025-05-06). https://kns.cnki.net/kcms/detail/21.1546.R.20250506.1357.040.html CHU Rui, SONG Yating, ZHOU Shengnan, et al. Observation on the curative effect of Shunao Jieyu decoction combined with moxibustion for regulating governor and relieving depression-transcranial magnetic stimulation(rTMS)on the rehabilitation of patients with post-stroke depression[J/OL]. Chinese Archives of Traditional Chinese Medicine, 2025: 1-11.(2025-05-06). https://kns.cnki.net/kcms/detail/21.1546.R.20250506.1357.040.html
[16] Ji XW, Wu CL, Wang XC, et al. Monoamine neurotransmitters and fibroblast growth factor-2 in the brains of rats with post-stroke depression[J]. Exp Ther Med, 2014, 8(1): 159-164.
[17] 黄海霞, 陈建, 张长春. 脑卒中后抑郁患者病变脑区功能磁共振影像特征分析[J]. 影像研究与医学应用, 2025, 9(2): 73-75.
[18] 孟旭. 血清HDAC3、FOXO1对卒中后抑郁的预测价值研究[J]. 国际检验医学杂志, 2025, 46(6): 757-761.
[19] Jin YH, Yu LM, Li Y. Paroxetine effect on nerve growth factor, human neurotrophin-4, brain-derived neurotrophic factor levels in post-stroke depression[J]. Mol Neurobiol, 2024, 61(10): 7890-7897.
[20] 王虹乔, 卢飞, 顾启功, 等. 毫火针留针五心穴联合重复经颅磁刺激治疗卒中后失眠的随机对照研究[J]. 世界复合医学(中英文), 2024, 10(12): 21-24. WANG Hongqiao, LU Fei, GU Qigong, et al. Randomized controlled study of filiform fire needle retaining Wuxin acupoint combined with repetitive transcranial magnetic stimulation in the treatment of insomnia after stroke[J]. World Journal of Complex Medicine, 2024, 10(12): 21-24.
[21] 赖欢, 龙珊珊, 蒲建林. 松果菊苷对慢性应激抑郁模型大鼠行为学及血清5-羟色胺相关神经递质代谢的影响[J]. 河北中医, 2025, 47(4): 600-605. LAI Huan, LONG Shanshan, PU Jianlin. Effect of echinacoside on behavior and serum 5-hydroxytryptamine in chronic stress-induced depression model rats[J]. Hebei Journal of Traditional Chinese Medicine, 2025, 47(4): 600-605.
[22] Zhang E, Liao P. Brain-derived neurotrophic factor and post-stroke depression[J]. J Neurosci Res, 2020, 98(3): 537-548.
[23] 刘晶晶, 周媛, 张小健, 等. 疏肝化瘀解郁汤结合针刺治疗卒中后抑郁效果及对患者身心健康影响[J/OL]. 中华中医药学刊, 2025: 1-11.(2025-02-24). https://kns.cnki.net/KCMS/detail/detail.aspx?filename=ZYHS20250221007&dbname=CJFD&dbcode=CJFQ LIU Jingjing, ZHOU Yuan, ZHANG Xiaojian, et al. Effect of Shugan Huayu Jieyu Decoction combined with acupuncture on post-stroke depression and its influence on patients physical and mental health[J/OL]. Chinese Archives of Traditional Chinese Medicine, 2025: 1-11.(2025-02-24). https://kns.cnki.net/KCMS/detail/detail.aspx?filename=ZYHS20250221007&dbname=CJFD&dbcode=CJFQ
[24] 刘乐, 朱宗俊, 罗金发, 等. “醒脑疏肝” 针法联合氟西汀治疗脑卒中后抑郁的效果及对血清5-羟色胺与去甲肾上腺素浓度的影响[J]. 中国临床保健杂志, 2025, 28(1): 78-82. LIU Le, ZHU Zongjun, LUO Jinfa, et al. Observation on the therapeutic effect of “Xingnao Shugan” acupuncture combined with fluoxetine on post-stroke depression and its impact on serum 5-HT and NE concentrations[J]. Chinese Journal of Clinical Healthcare, 2025, 28(1): 78-82.
[25] 李祎. 柴胡加龙骨牡蛎汤配合通督调神针刺治疗脑卒中后抑郁气郁化火型临床研究[J]. 实用中医药杂志, 2025, 41(4): 738-741.
[26] 孙培养, 蔡荣林, 李佩芳, 等. “通督调神”针刺对脑卒中后抑郁大鼠海马神经元保护作用及单胺类神经递质的影响[J]. 中国针灸, 2019, 39(7): 741-747. SUN Peiyang, CAI Ronglin, LI Peifang, et al. Protective effects on hippocampal neurons and the influence on hippocampal monoamine neurotransmitters with acupuncture for promoting the circulation of the governor vessel and regulating the mental state in rats with post-stroke depression[J]. Chinese Acupuncture & Moxibustion, 2019, 39(7): 741-747.
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