Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (3): 63-70.doi: 10.6040/j.issn.1671-7554.0.2024.1221

• Clinical Medicine • Previous Articles    

Effects of depression on sleep and cognitive function in patieuts with Parkinsons disease

ZHU Xiaoran1,2, LI Xiuhua2, REN Yanhong2, MAO Fei2, FANG Yuqing2, ZHAO Zhangning2, WANG Yalin2, LIU Tianhao2, ZHANG Yanqing1,2, HAN Rundong2   

  1. 1. School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, Shandong, China;
    2. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China
  • Published:2025-04-08

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Abstract: Objective To investigate the impact of depression on sleep and cognitive function in patients with Parkinsons disease(PD). Methods A total of 136 patients diagnosed with PD and hospitalised between 2018 and 2023 were carefully identified and categorised into PD with depression group(n=93)and PD without depression group(n=43), according to their Hamilton depression scale(HAMD)score. We collected sleep and cognition scale, such as Parkinsons disease sleep scale(PDSS), Montreal cognitive assessment(MoCA)and other clinical scales and polysomnography in the two groups. The Wilcoxon rank-sum test was used to assess discrepancies in sleep and cognitive metrics between the PD with depression group and the PD without depression group; the relationship between depression, cognitive function, and sleep quality was examined by Spearman rank correlation analysis; the risk factors associated with PD-related depression were examined by multiple linear regression analysis. Results ESS score and PDQ-39 scores in the PD with depression group were higher than those in the PD without depression group, whereas PDSS scores and MoCA scores were lower in the PD with depression group. Sleep latency in the PD with depression group was longer than that in the PD without depression group, and the differences were statistically significant(P<0.05). Depression scores were significantly correlated with MoCA and various sleep state scores(P<0.05). Multiple linear regression analysis showed that anxiety and quality of life had some predictive value for PD depression(P<0.05). Conclusion In PD patients, the more severe the depressive symptoms, the more severe the sleep disturbance and cognitive impairment, and the more impaired the quality of life.

Key words: Parkinsons disease, Depression, Sleep disturbance, Cognitive function, Quality of life

CLC Number: 

  • R742.5
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