Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (1): 76-80.doi: 10.6040/j.issn.1671-7554.0.2017.580

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Effects of sympathetic signals on orthodontic root resorption in rats

WANG Qianqian1,3, WANG Xuxia2,3, QIAO Qingfang1,3, WANG Yingzi1,3, YANG Panpan1,3, ZHANG Jun1,3   

  1. 1. Department of Orthodontics, Stomatological Hospital of Shandong University;
    2. Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Shandong University;
    3. Key Lab of Oral Biomedicine of Shandong Province, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the effects of sympathetic signals on root resorption in rats during orthodontic tooth movement. Methods Models of orthodontic tooth movement were established in 36 male 8-week old specific pathogen free(SPF)SD rats, which were randomly divided into 3 groups: propranolol(PRO)group, isoprenaline(ISO)group, and control group. The rats in the 3 groups were intraperitoneally injected with PRO［20 mg/(kg·d)］, ISO［5 mg/(kg·d)］ and isometric 0.9% saline, respectively, and were executed with force once every 7 days. After 14 days, the rats were sacrificed. The maxillae and first molars were separated. The root resorption was observed with hematoxylin-eosin(HE)staining.The volume of the mesial root of the first molars were measured with MicroCT. The differences among the 3 groups were compared using the SPSS 19.0 software. Results The results of HE staining showed that root resorption pits appeared in all 3 groups. The depth and scope of root resorption pits were the most serious in the ISO group, followed by the control and PRO groups. The results of MicroCT showed that the volume of mesial root of the first molars in the PRO group was larger than that in the control group(P<0.01), while the volume in the ISO group was obviously smaller than that in the control group(P<0.05). Conclusion Sympathetic signals can influence the root resorption during orthodontic tooth movement. The activation of signals promotes root resorption while the suppression of signals inhibits resorption.

Key words: Sympathetic nerve, Root resorption, MicroCT, Orthodontics, Rats

CLC Number: 

  • R783.5
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