Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (2): 23-27.doi: 10.6040/j.issn.1671-7554.0.2017.1013

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Clinical and radiological features of 36 adult patients with epidemic encephalitis B

MIAO Meng1, JIA Guoyong2, LIU Ying2, WANG Cuilan2   

  1. 1. Department of Neurology, Qilu Hospital of Shandong University(Qingdao), Qingdao 266035, Shandong, China;
    2. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-28

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Abstract: Objective To investigate clinical, cerebrospinal fluid(CSF)and radiological features of adult patients with epidemic encephalitis B. Methods The data were collected from 36 adult patients with epidemic encephalitis B who were diagnosed and treated in Qilu Hospital of Shandong University, from August to September in 2013. Results The patients with epidemic encephalitis B presented with fever(100%), consciousness and cognitive impairment, headache, nausea, vomiting(86.1%), and meningeal irritation(80.6%). Parkinson-like symptoms(30.6%)and seizure disorders(27.8%)were common. The IgM antibody against epidemic encephalitis B in serum and CSF was found. A total of 13 patients(54.2%)suffered intracranial hypertension, 22 patients displayed abnormal CSF cytology reaction, 16 patients(72.7%)displayed mixed-cell reaction, 6 patients(27.3%)appeared lymphocyte reaction. Protein content of 17 patients(70.8%)increased, IgG of 21 patients(87.5%)increased, IgA of 19 patients(79.2%)increased, and IgM of 23 patients(95.8%)increased. A total of 22 patients(61.1%)underwent brain MRI, 17 patients(47.2%)underwent brain CT. Neural damages displayed in thalamus(13 cases, 59.1%), midbrain(4 cases, 18.2%), basal ganglia(3 cases, 13.6%), hippocampus(3 cases, 13.6%)and other brain lobes(5 cases, 22.7%). A total of 4 patients(18.2%)were normal. Conclusion The patients with epidemic encephalitis B present acute encephalitic syndrome, 山 东 大 学 学 报 (医 学 版)56卷2期 -苗萌,等.36例成人流行性乙型脑炎临床分析和影像学特点 \=-accompanied with extrapyramid symptoms. The important features of CSF present the significant increase of the proportion of neutrophils and the prolonged duration of mixed-cell reaction. Neural damages commonly appear in thalamus.

Key words: Epidemic encephalitis B, Clinical features, Cerebrospinal fluid, Brain MRI, Adults

CLC Number: 

  • R512.32
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