Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (1): 81-86.doi: 10.6040/j.issn.1671-7554.0.2019.764

Previous Articles    

Clinical features of 9 cases of cryptogenic organizing pneumonia and literature review

WANG Huasheng1, OU Renjie2, WANG Mo3, BAI Longzhen2,LI Yingjie2, SUN Chao2, WANG Yongmei4   

  1. 1. Department of Thoracic Surgery, The Second Hospital of Shandong University, Jinan 250033, Shandong, China;
    2. Department of Thoracic Surgery, The Shandong Linglong Yingcheng Hospital, Zhaoyuan 265400, Shandong, China;
    3. Department of Vascular Surgery, Shandong Provincial Hospital Affilited to Shandong University, Jinan 250021, Shandong, China;
    4. Department of Cardiology, The Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Published:2022-09-27

PDF (PC)

35

Abstract: Objective To summarize cryptogenic orgenizing pneumonia(COP)s clinical and radiographic features. Methods Nine cases COP were reviewed. Their clinical presentation, radiographic and pathology features were analyzed. Results Cough(66.7%)and chest tightness(55.6%)were the most common symptoms in those patients. CRP and ESR were increased distinctly. Chest CT was characterized by bilateral or unilateral patchy or dffuse con-solidation(55.6%), and migration was its characteristic radiographic feature. In pathological staining, the alveoli and bronchioles were filled with loose fibroblast connective tissue thrombus, which was round or dumbbell-shaped. COP was sen-sitive to corticosteroid therapy, and had a good outcome. Conclusion COP has its own radiographic characteristics and sensitive to corticosteroid treatment. Attention should be paid to the disease to avoid misdiagnosis and mistreatment.

Key words: Cryptogenic organizing pneumonia, Clinical features, Radiographic characteristics, Corticosteroid

CLC Number: 

  • R563
[1] 邹春芳, 孙丽华, 闫海军, 等. 隐源性机化性肺炎误诊16例临床分析[J]. 临床误诊误治, 2018, 31(11): 1-5. ZOU Chunfang, SUN Lihua, YAN Haijun, et al. Clinical analysis of 16 cases of misdiagnosed cryptogenic organizing pneumonia[J]. Clinical Misdiagnosis & Mistherapy, 2018, 31(11): 1-5.
[2] 梅周芳, 钱凌, 都勇, 等. 隐源性机化性肺炎反复误诊为社区获得性肺炎[J]. 临床误诊误治, 2015, 28(7): 12-15. MEI Zhoufang, QIAN Ling, DU Yong, et al. Cryptogenic organizing pneumonia repeatedly misdiagnosed as community acquired pneumonia[J]. Clinical Misdiagnosis & Mistherapy, 2015, 28(7): 12-15.
[3] American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society(ATS), and the European Respiratory Society(ERS)was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001[J]. Am J Respir Crit Care Med, 2002, 165(2): 277-304.
[4] Davison AG, Heard BE, McAllister WA, et al. Cryptogenic organizing pneumonitis [J]. Q J Med, 1983, 52(207):382-394.
[5] 沈威, 李慧, 代静泓, 等. 隐源性机化性肺炎及结缔组织病相关性机化性肺炎的临床及影像特点分析[J]. 中华结核和呼吸杂志, 2015, 38(9): 669-674. SHEN Wei, LI Hui, DAI Jinghong, et al. Analysis for differences in clinical and radiologic findings between patients with cryptogenic organizing pneumonia and connective tissue disorder related organizing pneumonia[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2015, 38(9): 669-674.
[6] Radzikowska E, Ro(·overz)y A, Jagu sP, et al. Cryptogenic organizing pneumonia: IL-1β, IL-6, IL-8, and TGF-β1 serum concentrations and response to clarithromycin treatment[J]. Adv Exp Med Biol, 2016, 911: 77-85.
[7] 蔺晨, 郭芳, 季维娜, 等. 社区获得性肺炎患者的外周血TNF-α、sTREM-1、α1-APG水平[J]. 山东大学学报(医学版), 2015, 53(2): 61-64, 70. LIN Chen, GUO Fang, JI Weina, et al. Levels of peripheral blood TNF-α, sTREM-1 and α1-APG in community acquired pneumonia patients[J]. Journal of Shandong University(Health Sciences), 2015, 53(2): 61-64, 70.
[8] Drakopanagiotakis F, Paschalaki K, Abu-Hijleh M, et al. Cryptogenic and secondary organizing pneumonia: clinical presentation, radiographic findings, treatment response, and prognosis[J]. Chest, 2011, 139(4): 893-900.
[9] 娄和南, 毕卫群, 张亮, 等. 隐源性机化性肺炎的CT表现[J]. 青岛大学医学院学报, 2016, 52(3): 362-365. LOU Henan, BI Weiqun, ZHANG Liang, et al. Ct appearances of cryptogenic organizing pneumonia[J]. Acta Academiae Medicinae Qingdao Universitatis, 2016, 52(3): 362-365.
[10] 李惠萍, 范峰, 李秋红, 等. 肺活检证实隐源性机化性肺炎25例临床诊治体会[J]. 中华结核和呼吸杂志, 2007, 30(4): 259-264. doi:10.3760/j.issn:1001-0939.2007.04.009. LI Huiping, FAN Feng, LI Qiuhong, et al. Clinical analysis of 25 cases of biopsy-proven cryptogenic organizing pneumonia[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2007, 30(4): 259-264.
[11] Cavallasca JA, Caubet M, Helling CA, et al. Cryptogenic organizing pneumonia(COP), as presentation of rheumatoid arthritis[J]. Rheumatol Int, 2008, 29(1): 99-101.
[12] Aky gl FT, A gca M, Mısırlıo glu A, et al. Organizing Pneumonia as a Histopathological Term[J]. Turk Thorac J, 2017, 18(3):82-87.
[13] Radzikowska E, Ro(·overz)y A, Jagus P, et al. Clarithromycin decreases IL-6 concentration in serum and BAL fluid in patients with cryptogenic organizing pneumonia[J]. Adv Clin Exp Med, 2016, 25(5): 871-878.
[14] Pathak V, Kuhn JM, Durham C, et al. Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia[J]. Ann Am Thorac Soc, 2014, 11(1): 87-91.
[15] Cai MT, Bonella F, Dai HP, et al. Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumonia[J]. Immunobiology, 2013, 218(6): 930-937.
[16] Chang WJ, Lee EJ, Lee SY, et al. Successful salvage treatment of steroid-refractory bronchiolar COP with low-dose macrolides[J]. Pathol Int, 2012, 62(2): 144-148.
[17] Lee J, Cha SI, Park TI, et al. Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid[J]. Intern Med, 2011, 50(5): 475-479.
[18] Oh JH, Oh DJ, Koo SM, et al. Different responses to clarithromycin in patients with cryptogenic organizing pneumonia[J]. Tuberc Respir Dis(Seoul), 2015, 78(4): 401-407.
[19] Saito Z, Kaneko Y, Hasegawa T, et al. Predictive factors for relapse of cryptogenic organizing pneumonia[J]. BMC Pulm Med, 2019, 19(1): 10.
[20] 沈蕾蕾. 隐源性机化性肺炎的影像与临床及病理相关性研究[D]. 上海: 中国人民解放军海军军医大学, 2018. Shen Leilei. Cryptogenic organizing pneumonia: Analysis of Clinical-Radiologic-Pathological Features. Shanghai, The Second Military Medical University, 2018.
[1] YOU Xueting, TIAN Xingsong. Analysis of clinicopathological characteristics of 3 514 cases of breast cancer over 9 years [J]. Journal of Shandong University (Health Sciences), 2021, 59(1): 49-54.
[2] LI Fan, SHAO Jianhua, ZHAO Hongyu, DOU Chunhui, LÜ Yahui, LI Daqi. Clinical features and prognosis of adult secondary hemophagocytic syndrome: an analysis of 32 cases [J]. Journal of Shandong University (Health Sciences), 2019, 57(12): 62-67.
[3] YIN Xiaofang, GE Haibo. Epidemiological features of inpatients suffered from pulmonary tuberculosis with diabetes mellitus [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 58-61.
[4] SUN Ying, YU Jing, WEI Junmin, FAN Cong, WANG Xiuwen, GAO Peng, JIANG Liyu, MA Tingting. Clinical and pathological characteristics of breast carcinoma in women aged 35 years or younger [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(7): 71-74.
[5] ZHU Xide. Serum cortisol alterations after acute traumatic brain injury emergency operation [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(6): 58-61.
[6] ZHANG Tong-xia1, YAN Chuan-zhu1, ZHAO Xiu-he1, CHI Ling-yi2. Clinical and neuroimaging features of patients with
middle cerebral artery stenosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(11): 75-78.
[7] HUANG Ping, LING Xiao. Detection of glucocorticosteroid in traditional Chinese preparation by the liquidchromatographymass spectrometry method [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(12): 138-140.
[8] LI Jun,LI Yu,WANG Zhou,WANG Huan-yuan. Clinical features and surgical treatments for primary middle lobe carcinoma of the lung [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(11): 1066-1068.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd